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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Salmonella typhimurium
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotationSAAS annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotationSAAS annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseImported, LigaseUniRule annotationSAAS annotationImported, Transferase
Biological processPyridine nucleotide biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotationSAAS annotation (EC:6.3.4.21UniRule annotationSAAS annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotationImported
ORF Names:DD95_05170Imported, STMU2UK_00970Imported
OrganismiSalmonella typhimuriumImported
Taxonomic identifieri90371 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000054461 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK00763.

Family and domain databases

HAMAPiMF_00570. NAPRTase. 1 hit.
InterProiView protein in InterPro
IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR036068. Nicotinate_pribotase_like_C.
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiView protein in Pfam
PF04095. NAPRTase. 1 hit.
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0D6GSH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQFASPVLH SLLDTDAYKL HMQQAVFHHY YDVQVAAEFR CRGDDLLGIY
60 70 80 90 100
ADAIREQVDA MQHLRLLEDE FQWLSGLPFF KPDYLNWLRE FRYNPAQVCV
110 120 130 140 150
TNDNGKLNIR LTGPWREVIM WEVPLLAVIS ELVHHYRSPN AGVDQALDAL
160 170 180 190 200
ESKLVDFTAL TANLDMSRFH LMDFGTRRRF SREVQQAIVK RLQQESWFVG
210 220 230 240 250
TSNYDLARRL ALTPMGTQAH EWFQAHQQIS PDLATSQRAA LAAWLNEYPD
260 270 280 290 300
QLGIALTDCI TMDAFLRDFG IEFASRYQGL RHDSGDPVAW GEKAIAHYEK
310 320 330 340 350
LGIDPLTKTL VFSDNLDLPK AVELYRHFAS RVQLSFGIGT RLTCDIPQVK
360 370 380 390 400
PLNIVIKLVE CNGKPVAKLS DSPGKTICHD KAFVRALRKA FDLPQVRKAS
Length:400
Mass (Da):45,661
Last modified:May 27, 2015 - v1
Checksum:iBA76FF5EF0D02F3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JYVU01000011 Genomic DNA. Translation: KTZ14320.1.
LT855376 Genomic DNA. Translation: SMS04049.1.
RefSeqiWP_000191399.1. NZ_NDGU01000023.1.

Genome annotation databases

EnsemblBacteriaiKKE09838; KKE09838; TJ44_08720.
KTZ14320; KTZ14320; DD95_05170.
KEGGiseni:CY43_05135.
PATRICifig|90371.1185.peg.1070.

Similar proteinsi

Entry informationi

Entry nameiA0A0D6GSH3_SALTM
AccessioniPrimary (citable) accession number: A0A0D6GSH3
Secondary accession number(s): A0A0M2IYX8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: October 25, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported