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Protein

Arsenite methyltransferase

Gene

arsM

Organism
Clostridium sp.
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a methyl group from AdoMet to arsenite, producing methylated arsenicals. Involved in the conversion of As(III) to monomethylarsenic and the conversion of monomethylarsenic to dimethylarsenic. Reduces the arsenic toxicity in the cell and may contribute to the global arsenic cycling.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.1 Publication
S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processArsenical resistance
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenite methyltransferase1 Publication (EC:2.1.1.1371 Publication)
Gene namesi
Name:arsM1 Publication
OrganismiClostridium sp.
Taxonomic identifieri1506 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi65C → S: Cannot methylate arsenite, but can still methylate monomethylarsenic. 1 Publication1
Mutagenesisi153C → S: Lack of activity. 1 Publication1
Mutagenesisi203C → S: Lack of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004395931 – 270Arsenite methyltransferaseAdd BLAST270

Structurei

3D structure databases

ProteinModelPortaliA0A0D3MJQ5.
SMRiA0A0D3MJQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF13847. Methyltransf_31. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0D3MJQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNIREGVRQ KYAFAIANRG QGCCGSPGCC SDGLSDAADP ITGNLYDESD
60 70 80 90 100
LQGLDPELIA NSFGCGNPTA LMNLNLGEVV LDLGSGSGLD VLLSAKRVGP
110 120 130 140 150
TGKAYGLDMT DEMLAVAKEN QRKSGIENAE FLKGHIEEIP LAAKSIDVII
160 170 180 190 200
SNCVINLSGD KDKVLKEAYR VLKPQGRFAV SDIVIKRPLP EKIRDNILAW
210 220 230 240 250
AGCIAGAMTE EEYRGKLSRA GFENISLQVT REYNLEDPSL RGMLEDLTDG
260 270
EIKEFQGAMV SCFIRAAKPA
Length:270
Mass (Da):29,061
Last modified:May 27, 2015 - v1
Checksum:i0EBD5A2F604B8404
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ801487 Genomic DNA. Translation: AIM18906.1.

Similar proteinsi

Entry informationi

Entry nameiARSM_CLOSP
AccessioniPrimary (citable) accession number: A0A0D3MJQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2017
Last sequence update: May 27, 2015
Last modified: July 5, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families