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Protein
Submitted name:

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Gene

ARAP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2Imported
Gene namesi
Name:ARAP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000047365.11.
HGNCiHGNC:16924. ARAP2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000047365.

PTM / Processingi

Proteomic databases

PaxDbiA0A0C4DGW1.
PeptideAtlasiA0A0C4DGW1.

Expressioni

Gene expression databases

BgeeiENSG00000047365.
ExpressionAtlasiA0A0C4DGW1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A0C4DGW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 262PHInterPro annotationAdd BLAST126
Domaini375 – 556Rho-GAPInterPro annotationAdd BLAST182
Domaini585 – 679Ras-associatingInterPro annotationAdd BLAST95
Domaini693 – 796PHInterPro annotationAdd BLAST104

Phylogenomic databases

eggNOGiKOG1117. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 3 hits.
InterProiView protein in InterPro
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000159. RA_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
PfamiView protein in Pfam
PF01412. ArfGap. 1 hit.
PF00169. PH. 2 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 3 hits.
SM00324. RhoGAP. 1 hit.
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50729. SSF50729. 3 hits.
PROSITEiView protein in PROSITE
PS50003. PH_DOMAIN. 2 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0C4DGW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDASIWSNEL IELFIVIGNK RANDFWAGNL QKDEELHMDS PVEKRKNFIT
60 70 80 90 100
QKYKEGKFRK TLLASLTKEE LNKALCAAVV KPDVLETMAL LFSGADVMCA
110 120 130 140 150
TGDPVHSTPY LLAKKAGQSL QMEFLYHNKF SDFPQHDIHS EGVLSQESSQ
160 170 180 190 200
STFLCDFLYQ APSAASKLSS EKKLLEETNK KWCVLEGGFL SYYENDKSTT
210 220 230 240 250
PNGTININEV ICLAIHKEDF YLNTGPIFIF EIYLPSERVF LFGAETSQAQ
260 270 280 290 300
RKWTEAIAKH FVPLFAENLT EADYDLIGQL FYKDCHALDQ WRKGWFAMDK
310 320 330 340 350
SSLHFCLQMQ EVQGDRMHLR RLQELTISTM VQNGEKLDVL LLVEKGRTLY
360 370 380 390 400
IHGHTKLDFT VWHTAIEKAA GTDGNALQDQ QLSKNDVPII VNSCIAFVTQ
410 420 430 440 450
YGLGCKYIYQ KNGDPLHISE LLESFKKDAR SFKLRAGKHQ LEDVTAVLKS
460 470 480 490 500
FLSDIDDALL TKELYPYWIS ALDTQDDKER IKKYGAFIRS LPGVNRATLA
510 520 530 540 550
AIIEHLYRVQ KCSEINHMNA HNLALVFSSC LFQTKGQTSE EVNVIEDLIN
560 570 580 590 600
NYVEIFEVKE DQVKQMDIEN SFITKWKDTQ VSQAGDLLIE VYVERKEPDC
610 620 630 640 650
SIIIRISPVM EAEELTNDIL AIKNIIPTKG DIWATFEVIE NEELERPLHY
660 670 680 690 700
KENVLEQVLR WSSLAEPGSA YLVVKRFLTA DTIKHCSDRS TLGSIKEGIL
710 720 730 740 750
KIKEEPSKIL SGNKFQDRYF VLRDGFLFLY KDVKSSKHDK MFSLSSMKFY
760 770 780 790 800
RGVKKKMKPP TSWGLTAYSE KHHWHLCCDS SRTQTEWMTS IFIAQHEYDI
810 820 830 840 850
WPPAGKERKR SITKNPKIGG LPLIPIQHEG NATLARKILR VQEQNLKGCG
860
SVKSVIKSPW TLA
Length:863
Mass (Da):98,664
Last modified:April 1, 2015 - v1
Checksum:i03C133AB3FBFEAFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098827 Genomic DNA. No translation available.
AC104078 Genomic DNA. No translation available.
AC108033 Genomic DNA. No translation available.
AC109818 Genomic DNA. No translation available.
AC116623 Genomic DNA. No translation available.
AC139715 Genomic DNA. No translation available.
UniGeneiHs.479451.
Hs.591071.
Hs.739008.

Genome annotation databases

EnsembliENST00000618163; ENSP00000481036; ENSG00000047365.

Similar proteinsi

Entry informationi

Entry nameiA0A0C4DGW1_HUMAN
AccessioniPrimary (citable) accession number: A0A0C4DGW1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: October 25, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported