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Protein
Submitted name:

Nesprin-2

Gene

SYNE2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Nesprin-2Imported
Gene namesi
Name:SYNE2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000054654.15
HGNCiHGNC:17084 SYNE2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3490CytoplasmicPROSITE-ProRule annotationAdd BLAST3490
Topological domaini3512 – 3541Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000054654

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A0C4DGK3

Expressioni

Gene expression databases

BgeeiENSG00000054654
ExpressionAtlasiA0A0C4DGK3 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A0C4DGK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3482 – 3541KASHInterPro annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili119 – 139Sequence analysisAdd BLAST21
Coiled coili195 – 215Sequence analysisAdd BLAST21
Coiled coili326 – 353Sequence analysisAdd BLAST28
Coiled coili491 – 511Sequence analysisAdd BLAST21
Coiled coili519 – 539Sequence analysisAdd BLAST21
Coiled coili632 – 652Sequence analysisAdd BLAST21
Coiled coili666 – 693Sequence analysisAdd BLAST28
Coiled coili1132 – 1159Sequence analysisAdd BLAST28
Coiled coili1302 – 1329Sequence analysisAdd BLAST28
Coiled coili1467 – 1487Sequence analysisAdd BLAST21
Coiled coili1792 – 1826Sequence analysisAdd BLAST35
Coiled coili1846 – 1866Sequence analysisAdd BLAST21
Coiled coili1944 – 1964Sequence analysisAdd BLAST21
Coiled coili2140 – 2160Sequence analysisAdd BLAST21
Coiled coili2446 – 2466Sequence analysisAdd BLAST21
Coiled coili2471 – 2512Sequence analysisAdd BLAST42
Coiled coili3396 – 3416Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, TransmembranePROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00900000140842

Family and domain databases

InterProiView protein in InterPro
IPR012315 KASH
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR030266 SYNE2
PANTHERiPTHR45487 PTHR45487, 1 hit
PfamiView protein in Pfam
PF10541 KASH, 1 hit
PF00435 Spectrin, 4 hits
SMARTiView protein in SMART
SM01249 KASH, 1 hit
SM00150 SPEC, 14 hits
PROSITEiView protein in PROSITE
PS51049 KASH, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0C4DGK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDIYTNLS KMETVLGQSM SSLPLSYREA LERLEQSKAL VSNLISTKEE
60 70 80 90 100
LMKLRQILRL LRLRCTENDG ICLLKIVSAL WEKWLSLLEA AKEWEMWCEE
110 120 130 140 150
LKQEWKFVSE EIEREAIILD NLQEELPEIS KTKEAATTEE LSELLDCLCQ
160 170 180 190 200
YGENVEKQQL LLTLLLQRIR SIQNVPESSG AVETVPAFQE ITSMKERCNK
210 220 230 240 250
LLQKVQKNKE LVQTEIQERH SFTKEIIALK NFFQQTTTSF QNMAFQDHPE
260 270 280 290 300
KSEQFEELQS ILKKGKLTFE NIMEKLRIKY SEMYTIVPAE IESQVEECRK
310 320 330 340 350
ALEDIDEKIS NEVLKSSPSY AMRRKIEEIN NGLHNVEKML QQKSKNIEKA
360 370 380 390 400
QEIQKKMWDE LDLWHSKLNE LDSEVQDIVE QDPGQAQEWM DNLMIPFQQY
410 420 430 440 450
QQVSQRAECR TSQLNKATVK MEEYSDLLKS TEAWIENTSH LLANPADYDS
460 470 480 490 500
LRTLSHHAST VQMALEDSEQ KHNLLHSIFM DLEDLSIIFE TDELTQSIQE
510 520 530 540 550
LSNQVTALQQ KIMESLPQIQ RMADDVVAIE SEVKSMEKRV SKIKTILLSK
560 570 580 590 600
EIFDFSPEEH LKHGEVILEN IRPMKKTIAE IVSYQVELRL PQTGMKPLPV
610 620 630 640 650
FQRTNQLLQD IKLLENVTQE QNELLKVVIK QTNEWDEEIE NLKQILNNYS
660 670 680 690 700
AQFSLEHMSP DQADKLPQLQ GEIERMEKQI LSLNQRKEDL LVDLKATVLN
710 720 730 740 750
LHQHLKQEQE GVERDRLPAV TSEEGGVAER DASERKLNRR GSMSYLAAVE
760 770 780 790 800
EEVEESSVKS DNGDEKAEPS PQSWSSLWKH DKDMEEDRAS SSSGTIVQEA
810 820 830 840 850
YGKISTSDNS MAQILTPDSL NTEQGPECSL RPNQTEEGTT PPIEADTLDS
860 870 880 890 900
SDAQGGLEPR VEKTRPEPTE VLHACKTQVA ELELWLQQAN VAVEPETLNA
910 920 930 940 950
DMQQVLEQQL VGCQAMLTEI EHKVAFLLET CKDQGLGDNG ATQHEAEALS
960 970 980 990 1000
LKLKTVKCNL EKVQMMLQEK HSEDQHPTIL KKSSEPEHQE ALQPVNLSEL
1010 1020 1030 1040 1050
ESIVTERPQF SRQKDFQQQQ VLELKPMEQK DFIKFIEFNA KKMWPQYCQH
1060 1070 1080 1090 1100
DNDTTQESSA SNQASSPEND VPDSILSPQG QNGDKWQYLH HELSSKIKLP
1110 1120 1130 1140 1150
LPQLVEPQVS TNMGILPSVT MYNFRYPTTE ELKTYTTQLE DLRQEASNLQ
1160 1170 1180 1190 1200
TQENMTEEAY INLDKKLFEL FLTLSQCLSS VEEMLEMPRL YREDGSGQQV
1210 1220 1230 1240 1250
HYETLALELK KLYLALSDKK GDLLKAMTWP GENTNLLLEC FDNLQVCLEH
1260 1270 1280 1290 1300
TQAAAVCRSK SLKAGLDYNR SYQNEIKRLY HQLIKSKTSL QQSLNEISGQ
1310 1320 1330 1340 1350
SVAEQLQKAD AYTVELENAE SRVAKLRDEG ERLHLPYALL QEVYKLEDVL
1360 1370 1380 1390 1400
DSMWGMLRAR YTELSSPFVT ESQQDALLQG MVELVKIGKE KLAHGHLKQT
1410 1420 1430 1440 1450
KSKVALQAQI ENHKVFFQKL VADMLLIQAY SAKILPSLLQ NRETFWAEQV
1460 1470 1480 1490 1500
TEVKILEEKS RQCGMKLQSL LQKWEEFDEN YASLEKDLEI LISTLPSVSL
1510 1520 1530 1540 1550
VEETEERLVE RISFYQQIKR NIGGKHARLY QTLNEGKQLV ASVSCPELEG
1560 1570 1580 1590 1600
QIAKLEEQWL SLNKKIDHEL HRLQALLKHL LSYNRDSDQL TKWLESSQHT
1610 1620 1630 1640 1650
LNYWKEQSLN VSQDLDTIRS NINNFFEFSK EVDEKSSLKT AVISIGNQLL
1660 1670 1680 1690 1700
HLKETDTATL RASLAQFEQK WTMLITQLPD IQEKLHQLQM EKLPSRKAIT
1710 1720 1730 1740 1750
EMISWMNNVE HQTSDEDSVH SPSSASQVKH LLQKHKEFRM EMDYKQWIVD
1760 1770 1780 1790 1800
FVNQSLLQLS TCDVESKRYE RTEFAEHLGE MNRQWHRVHG MLNRKIQHLE
1810 1820 1830 1840 1850
QLLESITESE NKIQILNNWL EAQEERLKTL QKPESVISVQ KLLLDCQDIE
1860 1870 1880 1890 1900
NQLAIKSKAL DELKQSYLTL ESGAVPLLED TASRIDELFQ KRSSVLTQVN
1910 1920 1930 1940 1950
QLKTSMQSVL QEWKIYDQLY DEVNMMTIRF WYCMEHSKPV VLSLETLRCQ
1960 1970 1980 1990 2000
VENLQSLQDE AESSEGSWEK LQEVIGKLKG LCPSVAEIIE EKCQNTHKRW
2010 2020 2030 2040 2050
TQVNQAIADQ LQKAQSLLQL WKAYSNAHGE AAARLKQQEA KFQQLANISM
2060 2070 2080 2090 2100
SGNNLAEILP PALQDIKELQ HDVQKTKEAF LQNSSVLDRL PQPAESSTHM
2110 2120 2130 2140 2150
LLPGPLHSLQ RAAYLEKMLL VKANEFEFVL SQFKDFGVRL ESLKGLIMHE
2160 2170 2180 2190 2200
EENLDRLHQQ EKENPDSFLN HVLALTAQSP DIEHLNEVSL KLPLSDVAVK
2210 2220 2230 2240 2250
TLQNMNRQWI RATATALERC SELQGIGLNE KFLYCCEKWI QLLEKIEEAL
2260 2270 2280 2290 2300
KVDVANSLPE LLEQQKTYKM LEAEVSINQT IADSYVTQSL QLLDTTEIEN
2310 2320 2330 2340 2350
RPEFITEFSK LTDRWQNAVQ GVRQRKGDVD GLVRQWQDFT TSVENLFRFL
2360 2370 2380 2390 2400
TDTSHLLSAV KGQERFSLYQ TRSLIHELKN KEIHFQRRRT TCALTLEAGE
2410 2420 2430 2440 2450
KLLLTTDLKT KESVGRRISQ LQDSWKDMEP QLAEMIKQFQ STVETWDQCE
2460 2470 2480 2490 2500
KKIKELKSRL QVLKAQSEDP LPELHEDLHN EKELIKELEQ SLASWTQNLK
2510 2520 2530 2540 2550
ELQTMKADLT RHVLVEDVMV LKEQIEHLHR QWEDLCLRVA IRKQEIEDRL
2560 2570 2580 2590 2600
NTWVVFNEKN KELCAWLVQM ENKVLQTADI SIEEMIEKLQ KDCMEEINLF
2610 2620 2630 2640 2650
SENKLQLKQM GDQLIKASNK SRAAEIDDKL NKINDRWQHL FDVIGSRVKK
2660 2670 2680 2690 2700
LKETFAFIQQ LDKNMSNLRT WLARIESELS KPVVYDVCDD QEIQKRLAEQ
2710 2720 2730 2740 2750
QDLQRDIEQH SAGVESVFNI CDVLLHDSDA CANETECDSI QQTTRSLDRR
2760 2770 2780 2790 2800
WRNICAMSME RRMKIEETWR LWQKFLDDYS RFEDWLKSAE RTAACPNSSE
2810 2820 2830 2840 2850
VLYTSAKEEL KRFEAFQRQI HERLTQLELI NKQYRRLARE NRTDTASRLK
2860 2870 2880 2890 2900
QMVHEGNQRW DNLQRRVTAV LRRLRHFTNQ REEFEGTRES ILVWLTEMDL
2910 2920 2930 2940 2950
QLTNVEHFSE SDADDKMRQL NGFQQEITLN TNKIDQLIVF GEQLIQKSEP
2960 2970 2980 2990 3000
LDAVLIEDEL EELHRYCQEV FGRVSRFHRR LTSCTPGLED EKEASENETD
3010 3020 3030 3040 3050
MEDPREIQTD SWRKRGESEE PSSPQSLCHL VAPGHERSGC ETPVSVDSIP
3060 3070 3080 3090 3100
LEWDHTGDVG GSSSHEEDEE GPYYSALSDV EIPENPEAYL KMTTKTLKAS
3110 3120 3130 3140 3150
SGKSISDGHS WHVPDSPSCP EHHYKQMEGD RNVPPVPPAS STPYKPPYGK
3160 3170 3180 3190 3200
LLLPPGTDGG KEGPRVLNGN PQQEDGGLAG ITEQQSGAFD RWEMIQAQEL
3210 3220 3230 3240 3250
HNKLKIKQNL QQLNSDISAI TTWLKKTEAE LEMLKMAKPP SDIQEIELRV
3260 3270 3280 3290 3300
KRLQEILKAF DTYKALVVSV NVSSKEFLQT ESPESTELQS RLRQLSLLWE
3310 3320 3330 3340 3350
AAQGAVDSWR GGLRQSLMQC QDFHQLSQNL LLWLASAKNR RQKAHVTDPK
3360 3370 3380 3390 3400
ADPRALLECR RELMQLEKEL VERQPQVDML QEISNSLLIK GHGEDCIEAE
3410 3420 3430 3440 3450
EKVHVIEKKL KQLREQVSQD LMALQGTQNP ASPLPSFDEV DSGDQPPATS
3460 3470 3480 3490 3500
VPAPRAKFRA VRTTEGEEET ESRVPGSTRP QRSFLSRVVR AALPLQLLLL
3510 3520 3530 3540
LLLLLACLLP SSEEDYSCTQ ANNFARSFYP MLRYTNGPPP T
Length:3,541
Mass (Da):408,729
Last modified:April 1, 2015 - v1
Checksum:iAB9CF87A5A1A397C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162832 Genomic DNA No translation available.
AL355094 Genomic DNA No translation available.
AL359235 Genomic DNA No translation available.
UniGeneiHs.745014

Genome annotation databases

EnsembliENST00000555002; ENSP00000450831; ENSG00000054654

Similar proteinsi

Entry informationi

Entry nameiA0A0C4DGK3_HUMAN
AccessioniPrimary (citable) accession number: A0A0C4DGK3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: June 20, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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