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Protein
Submitted name:

Glutamate--cysteine ligase catalytic subunit

Gene

GCLC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate--cysteine ligase catalytic subunitImported
Gene namesi
Name:GCLCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000001084.10.
HGNCiHGNC:4311. GCLC.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000001084.

PTM / Processingi

Proteomic databases

PaxDbiA0A0C4DGB2.
PeptideAtlasiA0A0C4DGB2.

Expressioni

Gene expression databases

BgeeiENSG00000001084.
ExpressionAtlasiA0A0C4DGB2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A0C4DGB2.
SMRiA0A0C4DGB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3754. Eukaryota.
ENOG410XQIG. LUCA.
GeneTreeiENSGT00390000011908.

Family and domain databases

InterProiView protein in InterPro
IPR004308. GCS.
IPR014746. Gln_synth/guanido_kin_cat_dom.
PANTHERiPTHR11164. PTHR11164. 1 hit.
SUPFAMiSSF55931. SSF55931. 2 hits.

Sequencei

Sequence statusi: Complete.

A0A0C4DGB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLSQGSPL SWEETKRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE
60 70 80 90 100
VEYMLVSFDH ENKKVRLVLS GEKVLETLQE KGERTNPNHP TLWRPEYGSY
110 120 130 140 150
MIEGTPGQPY GGTMSEFNTV EANMRKRRKE ATSILEENQA LCTITSFPRL
160 170 180 190 200
GCPGFTLPEV KPNPVEGGAS KSLFFPDEAI NKHPRFSTLT RNIRHRRGEK
210 220 230 240 250
VVINVPIFKD KNTPSPFIET FTEDDEASRA SKPDHIYMDA MGFGMGNCCL

QV
Length:252
Mass (Da):28,752
Last modified:April 1, 2015 - v1
Checksum:iFFE1AF8A2C3BB1B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL033397 Genomic DNA. No translation available.
UniGeneiHs.654465.

Genome annotation databases

EnsembliENST00000514004; ENSP00000421908; ENSG00000001084.

Similar proteinsi

Entry informationi

Entry nameiA0A0C4DGB2_HUMAN
AccessioniPrimary (citable) accession number: A0A0C4DGB2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: October 25, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported