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Protein
Submitted name:

Rho guanine nucleotide exchange factor 4

Gene

ARHGEF4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 4Imported
Gene namesi
Name:ARHGEF4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000136002.16
HGNCiHGNC:684 ARHGEF4

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136002

Expressioni

Gene expression databases

BgeeiENSG00000136002
ExpressionAtlasiA0A0C4DFY6 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 278SH3InterPro annotationAdd BLAST60
Domaini309 – 493DHInterPro annotationAdd BLAST185
Domaini524 – 631PHInterPro annotationAdd BLAST108

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3519 Eukaryota
ENOG410XT9S LUCA
GeneTreeiENSGT00900000140796

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A0C4DFY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XEGGQGPRGL GTVPWLRDLP GSENHMPWEE PAGEKPSCSH SQKAFHMEPA
60 70 80 90 100
QKPCFTTDMV TWALLCISAE TVRGEAPSQP RGIPHRSPVS VDDLWLEKTQ
110 120 130 140 150
RKKLQKQAHV ERRLHIGAVH KDGVKCWRKT IITSPESLNL PRRSHPLSQS
160 170 180 190 200
APTGLNHMGW PEHTPGTAMP DGALDTAVCA DEVGSEEDLY DDLHSSSHHY
210 220 230 240 250
SHPGGGGEQL AINELISDGS VVCAEALWDH VTMDDQELGF KAGDVIEVMD
260 270 280 290 300
ATNREWWWGR VADGEGWFPA SFVRLRVNQD EPADDDAPLA GNSGAEDGGA
310 320 330 340 350
EAQSSKDQMR TNVINEILST ERDYIKHLRD ICEGYVRQCR KRADMFSEEQ
360 370 380 390 400
LRTIFGNIED IYRCQKAFVK ALEQRFNRER PHLSELGACF LEHQADFQIY
410 420 430 440 450
SEYCNNHPNA CVELSRLTKL SKYVYFFEAC RLLQKMIDIS LDGFLLTPVQ
460 470 480 490 500
KICKYPLQLA ELLKYTHPQH RDFKDVEAAL HAMKNVAQLI NERKRRLENI
510 520 530 540 550
DKIAQWQSSI EDWEGEDLLV RSSELIYSGE LTRVTQPQAK SQQRMFFLFD
560 570 580 590 600
HQLIYCKKDL LRRDVLYYKG RLDMDGLEVV DLEDGKDRDL HVSIKNAFRL
610 620 630 640 650
HRGATGDSHL LCTRKPEQKQ RWLKAFARER EQVQLDQETG FSITELQRKQ
660 670 680 690
AMLNASKQQV TGKPKGRRTA APPPRLPGPY PADIIPFSEP QSQAS
Length:695
Mass (Da):79,043
Last modified:October 5, 2016 - v2
Checksum:iD933D519C5D875A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009477 Genomic DNA No translation available.
AC112786 Genomic DNA No translation available.
AC133785 Genomic DNA No translation available.
KF456708 Genomic DNA No translation available.
KF456713 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000392953; ENSP00000376680; ENSG00000136002

Similar proteinsi

Entry informationi

Entry nameiA0A0C4DFY6_HUMAN
AccessioniPrimary (citable) accession number: A0A0C4DFY6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: October 5, 2016
Last modified: May 23, 2018
This is version 31 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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