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Protein
Submitted name:

Rho guanine nucleotide exchange factor 4

Gene

ARHGEF4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 4Imported
Gene namesi
Name:ARHGEF4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000136002.16.
HGNCiHGNC:684. ARHGEF4.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136002.

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A0C4DFY6.

Expressioni

Gene expression databases

BgeeiENSG00000136002.
ExpressionAtlasiA0A0C4DFY6. baseline and differential.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 278SH3InterPro annotationAdd BLAST53
Domaini309 – 493DHInterPro annotationAdd BLAST185
Domaini524 – 631PHInterPro annotationAdd BLAST108

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3519. Eukaryota.
ENOG410XT9S. LUCA.
GeneTreeiENSGT00900000140796.

Family and domain databases

CDDicd00160. RhoGEF. 1 hit.
Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR035899. DBL_dom_sf.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH-like_dom_sf.
IPR001849. PH_domain.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Fragment.

A0A0C4DFY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XEGGQGPRGL GTVPWLRDLP GSENHMPWEE PAGEKPSCSH SQKAFHMEPA
60 70 80 90 100
QKPCFTTDMV TWALLCISAE TVRGEAPSQP RGIPHRSPVS VDDLWLEKTQ
110 120 130 140 150
RKKLQKQAHV ERRLHIGAVH KDGVKCWRKT IITSPESLNL PRRSHPLSQS
160 170 180 190 200
APTGLNHMGW PEHTPGTAMP DGALDTAVCA DEVGSEEDLY DDLHSSSHHY
210 220 230 240 250
SHPGGGGEQL AINELISDGS VVCAEALWDH VTMDDQELGF KAGDVIEVMD
260 270 280 290 300
ATNREWWWGR VADGEGWFPA SFVRLRVNQD EPADDDAPLA GNSGAEDGGA
310 320 330 340 350
EAQSSKDQMR TNVINEILST ERDYIKHLRD ICEGYVRQCR KRADMFSEEQ
360 370 380 390 400
LRTIFGNIED IYRCQKAFVK ALEQRFNRER PHLSELGACF LEHQADFQIY
410 420 430 440 450
SEYCNNHPNA CVELSRLTKL SKYVYFFEAC RLLQKMIDIS LDGFLLTPVQ
460 470 480 490 500
KICKYPLQLA ELLKYTHPQH RDFKDVEAAL HAMKNVAQLI NERKRRLENI
510 520 530 540 550
DKIAQWQSSI EDWEGEDLLV RSSELIYSGE LTRVTQPQAK SQQRMFFLFD
560 570 580 590 600
HQLIYCKKDL LRRDVLYYKG RLDMDGLEVV DLEDGKDRDL HVSIKNAFRL
610 620 630 640 650
HRGATGDSHL LCTRKPEQKQ RWLKAFARER EQVQLDQETG FSITELQRKQ
660 670 680 690
AMLNASKQQV TGKPKGRRTA APPPRLPGPY PADIIPFSEP QSQAS
Length:695
Mass (Da):79,043
Last modified:October 5, 2016 - v2
Checksum:iD933D519C5D875A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009477 Genomic DNA. No translation available.
AC112786 Genomic DNA. No translation available.
AC133785 Genomic DNA. No translation available.
KF456708 Genomic DNA. No translation available.
KF456713 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000392953; ENSP00000376680; ENSG00000136002.

Similar proteinsi

Entry informationi

Entry nameiA0A0C4DFY6_HUMAN
AccessioniPrimary (citable) accession number: A0A0C4DFY6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: October 5, 2016
Last modified: January 31, 2018
This is version 28 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported