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Protein

Tubulin alpha chain

Gene

SPBR_08303

Organism
Sporothrix brasiliensis 5110
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin alpha chainUniRule annotation
Gene namesi
ORF Names:SPBR_08303Imported
OrganismiSporothrix brasiliensis 5110Imported
Taxonomic identifieri1398154 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeOphiostomatalesOphiostomataceaeSporothrix
Proteomesi
  • UP000031575 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonSAAS annotation, MicrotubuleUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 247TubulinInterPro annotationAdd BLAST198
Domaini249 – 399Tubulin_CInterPro annotationAdd BLAST151

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiView protein in InterPro
IPR002452. Alpha_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR037103. Tubulin/FtsZ_C_sf.
IPR036525. Tubulin/FtsZ_GTPase_sf.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiView protein in Pfam
PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
PRINTSiPR01162. ALPHATUBULIN.
PR01161. TUBULIN.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiView protein in PROSITE
PS00227. TUBULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0C2IAP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGEVLHLHL GQAGTQLGNS AWELYLLEHG LSADGRPDPN LKDIGEGGSY
60 70 80 90 100
ETFFTETSNG KYVPRSIFVD LDPSPIDEIR TGNYRQLFHP ELLISGKEDA
110 120 130 140 150
ANNYARGHYT IGKEMVDNVI DRIRRVADNC NSLQGFLIFH SFGGGTGSGF
160 170 180 190 200
GALLLERLST EYGKKCKLEF AIYPAPRVST AVVEPYNAVL STHSTIENSD
210 220 230 240 250
CTFLVDNEAV YDICRRNLDI PRPDYEHLNR LIAQVVSSIT SSLRFDGALN
260 270 280 290 300
VDLNEFQTNL VPYPRIHYPL ISYAPVVSAS KSAHESFKVH DLTFQCFEPN
310 320 330 340 350
NQMVVCDPRN GKYMAVALLY RGDVVPRDCN AAVAALKAKA SFNLVEWCPT
360 370 380 390 400
GFKIGINYQK PVAVPTASPT DGGLASVDRS VSMLSNTTAI AEAWSRLDHK
410 420 430 440 450
FDLMYSKRAF VHWYVGEGME EGEFSEARED LAALEKDYEE VAADSFEAEE

GDIEY
Length:455
Mass (Da):50,516
Last modified:April 1, 2015 - v1
Checksum:iC3756480BF04D3FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AWTV01000011 Genomic DNA. Translation: KIH86301.1.

Genome annotation databases

EnsemblFungiiKIH86301; KIH86301; SPBR_08303.

Similar proteinsi

Entry informationi

Entry nameiA0A0C2IAP2_9PEZI
AccessioniPrimary (citable) accession number: A0A0C2IAP2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: October 25, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported