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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotationSAAS annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_1), Orotate phosphoribosyltransferase (pyrE_2), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_3), Orotate phosphoribosyltransferase (pyrE_1), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_4), Orotate phosphoribosyltransferase (pyrE_3), Orotate phosphoribosyltransferase (pyrE_1), Orotate phosphoribosyltransferase (pyrE_1), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_2), Orotate phosphoribosyltransferase (pyrE_1), Orotate phosphoribosyltransferase (pyrE_2), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_2), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_2), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_2), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_1), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_1), Orotate phosphoribosyltransferase (pyrE_2), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_1), Orotate phosphoribosyltransferase (pyrE_2), Orotate phosphoribosyltransferase (pyrE_1), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_1), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_1), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_2), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE_2), Orotate phosphoribosyltransferase (pyrE_3)
  2. Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF_1), Orotidine 5'-phosphate decarboxylase (pyrF_1), Orotidine 5'-phosphate decarboxylase (pyrF_1), Orotidine 5'-phosphate decarboxylase (pyrF_1), Orotidine 5'-phosphate decarboxylase (pyrF_1), Orotidine 5'-phosphate decarboxylase (pyrF_2), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF_1), Orotidine 5'-phosphate decarboxylase (pyrF_1), Orotidine 5'-phosphate decarboxylase (pyrF_2), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF_1), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF_2), Orotidine 5'-phosphate decarboxylase (pyrF_2), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF_1), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (ERS367886_01649), Orotidine 5'-phosphate decarboxylase (pyrF_1), Orotidine 5'-phosphate decarboxylase (pyrF_2), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF_1), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF_2), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF_3), Orotidine 5'-phosphate decarboxylase (pyrF_1), Orotidine 5'-phosphate decarboxylase (pyrF), Orotidine 5'-phosphate decarboxylase (pyrF_1)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11SubstrateUniRule annotation1
Binding sitei34SubstrateUniRule annotation1
Active sitei63Proton donorUniRule annotation1
Binding sitei117SubstrateUniRule annotation1
Binding sitei179SubstrateUniRule annotation1
Binding sitei188SubstrateUniRule annotation1
Binding sitei208Substrate; via amide nitrogenUniRule annotation1
Binding sitei209SubstrateUniRule annotation1

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, Lyase
Biological processPyrimidine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotationImported
ORF Names:ERS019420_01823Imported, ERS020521_00929Imported, ERS043879_02513Imported
OrganismiStreptococcus pneumoniaeImported
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000042694 Componenti: Unassembled WGS sequence
  • UP000235698 Componenti: Unassembled WGS sequence
  • UP000042569 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 224OMPdecaseInterPro annotationAdd BLAST220

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 70Substrate bindingUniRule annotation10

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4106EG9 Bacteria
COG0284 LUCA

Family and domain databases

Gene3Di3.20.20.701 hit
HAMAPiMF_01200_B OMPdecase_type1_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR32119:SF2 PTHR32119:SF2, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0B7LY28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREHRPIIAL DFPSFEAVKE FLALFPAEES LYLKVGMELY YAAGPEIVSY
60 70 80 90 100
LKGLGHSVFL DLKLHDIPNT VKSAMKILSQ LGVDMTNVHA AGGVEMMKAA
110 120 130 140 150
REGLGSQAKL IAVTQLTSTS EAQMQEFQNI QTSLQESVIH YAKKTAEAGL
160 170 180 190 200
DGVVCSAQEV QVIKQATNPD FICLTPGIRP AGVAVGDQKR VMTPADAYQI
210 220 230
GSDYIVVGRP ITQAEEPVAA YHAIKDEWTQ DWN
Length:233
Mass (Da):25,437
Last modified:April 1, 2015 - v1
Checksum:i29AAED8BCBF7B4C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CKOB01000026 Genomic DNA Translation: CIX00022.1
CGXO01000014 Genomic DNA Translation: COP12583.1
CNOG02000039 Genomic DNA Translation: CTO23858.1
RefSeqiWP_001206713.1, NZ_NNBX01000025.1

Similar proteinsi

Entry informationi

Entry nameiA0A0B7LY28_STREE
AccessioniPrimary (citable) accession number: A0A0B7LY28
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: April 25, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported