pyrF

Functionⁱ

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotationSAAS annotation

Catalytic activityⁱ

Orotidine 5'-phosphate = UMP + CO₂.UniRule annotation

Pathwayⁱ: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	11	SubstrateUniRule annotation	1
Binding siteⁱ	34	SubstrateUniRule annotation	1
Active siteⁱ	63	Proton donorUniRule annotation	1
Binding siteⁱ	117	SubstrateUniRule annotation	1
Binding siteⁱ	179	SubstrateUniRule annotation	1
Binding siteⁱ	188	SubstrateUniRule annotation	1
Binding siteⁱ	208	Substrate; via amide nitrogenUniRule annotation	1
Binding siteⁱ	209	SubstrateUniRule annotation	1

Keywordsⁱ

Molecular function	DecarboxylaseUniRule annotation, Lyase
Biological process	Pyrimidine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayⁱ	UPA00070; UER00120

UniPathwayⁱ

UPA00070; UER00120

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation) Alternative name(s): OMP decarboxylaseUniRule annotation Short name: OMPDCaseUniRule annotation Short name: OMPdecaseUniRule annotation
Gene namesⁱ	Name:pyrFUniRule annotationImported ORF Names:ERS019420_01823Imported, ERS020521_00929Imported, ERS043879_02513Imported
Organismⁱ	Streptococcus pneumoniaeImported
Taxonomic identifierⁱ	1313 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus
Proteomesⁱ	UP000042694 Componentⁱ: Unassembled WGS sequence UP000235698 Componentⁱ: Unassembled WGS sequence UP000042569 Componentⁱ: Unassembled WGS sequence

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotationSAAS annotation

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 224	OMPdecaseInterPro annotationAdd BLAST		220

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	61 – 70	Substrate bindingUniRule annotation		10

Sequence similaritiesⁱ

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG4106EG9 Bacteria COG0284 LUCA

eggNOGⁱ

ENOG4106EG9 Bacteria
COG0284 LUCA

Family and domain databases

Gene3Dⁱ	3.20.20.701 hit
HAMAPⁱ	MF_01200_B OMPdecase_type1_B, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR014732 OMPdecase IPR018089 OMPdecase_AS IPR001754 OMPdeCOase_dom IPR011060 RibuloseP-bd_barrel
PANTHERⁱ	PTHR32119:SF2 PTHR32119:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00215 OMPdecase, 1 hit
SMARTⁱ	View protein in SMART SM00934 OMPdecase, 1 hit
SUPFAMⁱ	SSF51366 SSF51366, 1 hit
TIGRFAMsⁱ	TIGR01740 pyrF, 1 hit
PROSITEⁱ	View protein in PROSITE PS00156 OMPDECASE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A0B7LY28-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MREHRPIIAL DFPSFEAVKE FLALFPAEES LYLKVGMELY YAAGPEIVSY 
        60         70         80         90        100
LKGLGHSVFL DLKLHDIPNT VKSAMKILSQ LGVDMTNVHA AGGVEMMKAA 
       110        120        130        140        150
REGLGSQAKL IAVTQLTSTS EAQMQEFQNI QTSLQESVIH YAKKTAEAGL 
       160        170        180        190        200
DGVVCSAQEV QVIKQATNPD FICLTPGIRP AGVAVGDQKR VMTPADAYQI 
       210        220        230 
GSDYIVVGRP ITQAEEPVAA YHAIKDEWTQ DWN

Length:233

Mass (Da):25,437

Last modified:April 1, 2015 - v1

Checksum:ⁱ29AAED8BCBF7B4C9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CKOB01000026 Genomic DNA Translation: CIX00022.1 CGXO01000014 Genomic DNA Translation: COP12583.1 CNOG02000039 Genomic DNA Translation: CTO23858.1
NCBI Reference Sequences More...RefSeqⁱ	WP_001206713.1, NZ_NNBX01000025.1

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A0B7LY28	Q04LJ3 B2IN86 Q8DQL6 J0VAT6 UPI0009A1BB99	Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) Streptococcus pneumoniae (strain CGSP14) Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Streptococcus pneumoniae 2070335 Streptococcus pneumoniae	233	UniRef100_Q04LJ3	Cluster: Orotidine 5'-phosphate decarboxylase	6

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A0B7LY28	Q04LJ3 B2IN86 Q8DQL6 J0VAT6 UPI0009A1BB99 A0A1B1IFG2 A0A0F2D685 F5VT79 A0A1X1G748 A0A1X1GG41 +308	Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) Streptococcus pneumoniae (strain CGSP14) Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Streptococcus pneumoniae 2070335 Streptococcus pneumoniae Streptococcus sp. oral taxon 064 Streptococcus oralis subsp. oralis Streptococcus oralis SK255 Streptococcus oralis subsp. tigurinus Streptococcus pneumoniae serotype 19F (strain G54) And more	233	UniRef90_Q04LJ3	Cluster: Orotidine 5'-phosphate decarboxylase	319

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A0B7LY28	Q5L0U0 UPI0001754449 G8N150 T0NQE2 X5HYC6 A0A163YME5 A0A2M9T7C5 UPI000BB8BFE1 X5IDP5 UPI0005CCF3E8 +2014	Geobacillus kaustophilus (strain HTA426) Geobacillus thermoleovorans CCB_US3_UF5 Geobacillus sp. A8 Bacillus caldolyticus Geobacillus sp. 15 Geobacillus sp. WSUCF-018B Geobacillus sp. FJAT-46040 Geobacillus subterraneus Anoxybacillus geothermalis Geobacillus thermoleovorans (Bacillus thermoleovorans) And more	244	UniRef50_Q5L0U0	Cluster: Orotidine 5'-phosphate decarboxylase	2,025

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CKOB01000026 Genomic DNA Translation: CIX00022.1 CGXO01000014 Genomic DNA Translation: COP12583.1 CNOG02000039 Genomic DNA Translation: CTO23858.1
NCBI Reference Sequences More...RefSeqⁱ	WP_001206713.1, NZ_NNBX01000025.1

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	ENOG4106EG9 Bacteria COG0284 LUCA

eggNOGⁱ

ENOG4106EG9 Bacteria
COG0284 LUCA

Enzyme and pathway databases

UniPathwayⁱ	UPA00070; UER00120

UniPathwayⁱ

UPA00070; UER00120

Family and domain databases

Gene3Dⁱ	3.20.20.701 hit
HAMAPⁱ	MF_01200_B OMPdecase_type1_B, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR014732 OMPdecase IPR018089 OMPdecase_AS IPR001754 OMPdeCOase_dom IPR011060 RibuloseP-bd_barrel
PANTHERⁱ	PTHR32119:SF2 PTHR32119:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00215 OMPdecase, 1 hit
SMARTⁱ	View protein in SMART SM00934 OMPdecase, 1 hit
SUPFAMⁱ	SSF51366 SSF51366, 1 hit
TIGRFAMsⁱ	TIGR01740 pyrF, 1 hit
PROSITEⁱ	View protein in PROSITE PS00156 OMPDECASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A0B7LY28_STREE
Accessionⁱ	A0A0B7LY28Primary (citable) accession number: A0A0B7LY28
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 1, 2015
	Last sequence update:	April 1, 2015
	Last modified:	April 25, 2018
	This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB - A0A0B7LY28 (A0A0B7LY28_STREE)

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Orotidine 5'-phosphate decarboxylase

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: UMP biosynthesis via de novo pathway

Sites

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Interactionⁱ

Subunit structureⁱ

Family & Domainsⁱ

Domains and Repeats

Region

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A0B7LY28 (A0A0B7LY28_STREE)

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Orotidine 5'-phosphate decarboxylase

pyrF

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: UMP biosynthesis via de novo pathway

Sites

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

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Functionⁱ

Pathwayⁱ: UMP biosynthesis via de novo pathway

Names & Taxonomyⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ