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Protein

Envelope glycoprotein L

Gene

BKRF2

Organism
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Biological processi

Keywordsi

Biological processFusion of virus membrane with host cell membraneUniRule annotation, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein LUniRule annotation
Short name:
gLUniRule annotation
Gene namesi
Name:BKRF2Imported
Synonyms:gLUniRule annotation
OrganismiEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)Imported
Taxonomic identifieri10376 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000158635 Componenti: Genome
  • UP000145728 Componenti: Genome

Subcellular locationi

  • Virion membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Extracellular side UniRule annotation
  • Host cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Extracellular side UniRule annotation
  • host trans-Golgi network UniRule annotation
  • Note: gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotation, Host Golgi apparatusUniRule annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationImported, Virion

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Interactioni

Subunit structurei

Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.UniRule annotation

Structurei

3D structure databases

SMRiA0A0B6VN64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae glycoprotein L family.UniRule annotation

Phylogenomic databases

KOiK19452

Family and domain databases

Gene3Di1.20.120.1580, 1 hit
HAMAPiMF_04034 HSV_GL_alphagamma, 1 hit
InterProiView protein in InterPro
IPR020175 Herpes_gL_rhadinovirus
IPR038313 Herpes_gL_rhadinovirus_sf
IPR034708 HSV_GL_alphagamma
PfamiView protein in Pfam
PF11108 Phage_glycop_gL, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009419 Herpes_gL_rhadinovirus, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0B6VN64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVGVFLAI CLVTIFVLPT WGNWAYPCCH VTQLRAQHLL ALENISDIYL
60 70 80 90 100
VSNQTCDGFS LASLNSPKNG SNQLVISRCA NGLNVVSFFI SILKRSSSAL
110 120 130
TGHLRELLTT LETLYGSFSV EDLFGANLNR YAWHRGG
Length:137
Mass (Da):15,080
Last modified:April 1, 2015 - v1
Checksum:iF0C03CDACD1893A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB850645 Genomic DNA Translation: BAQ20095.1
AB850654 Genomic DNA Translation: BAQ20318.1
LN827555 Genomic DNA Translation: CEQ34682.1
LN827572 Genomic DNA Translation: CEQ36155.1
LN827586 Genomic DNA Translation: CEQ37311.1
LN827589 Genomic DNA Translation: CEQ37559.1
LN827597 Genomic DNA Translation: CEQ38221.1
LN827739 Genomic DNA Translation: CEQ43300.1
RefSeqiYP_401678.1, NC_007605.1

Genome annotation databases

GeneIDi3783710
KEGGivg:3783710

Similar proteinsi

Entry informationi

Entry nameiA0A0B6VN64_EBVG
AccessioniPrimary (citable) accession number: A0A0B6VN64
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: March 28, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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