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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processAntibiotic resistanceUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
ORF Names:A9486_24590Imported, ABW01_10880Imported, BVG01_08505Imported, COL95_25870Imported, MCCC1A01412_10525Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000183215 Componenti: Unassembled WGS sequence
  • UP000181973 Componenti: Unassembled WGS sequence
  • UP000224851 Componenti: Unassembled WGS sequence
  • UP000191148 Componenti: Unassembled WGS sequence
  • UP000035904 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei44 – 62HelicalUniRule annotationAdd BLAST19
Transmembranei82 – 103HelicalUniRule annotationAdd BLAST22
Transmembranei109 – 130HelicalUniRule annotationAdd BLAST22
Transmembranei142 – 162HelicalUniRule annotationAdd BLAST21
Transmembranei182 – 203HelicalUniRule annotationAdd BLAST22
Transmembranei215 – 238HelicalUniRule annotationAdd BLAST24
Transmembranei244 – 262HelicalUniRule annotationAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
KOiK06153

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0B5UBN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADWLIGIIM GAVEGLTEFL PVSSTGHMIL TGHLIGFDDD RAKVFEVVIQ
60 70 80 90 100
LGSILAVVVI FWKRLWSLVG IGKVTDGPSL NLLHIIIGMI PAGVLGVLFH
110 120 130 140 150
SAIKEVLFGP GPVVISLVAG GILMIVAEKF SKPSTARTLD EITYKQAFTI
160 170 180 190 200
GMFQCLALWP GFSRSGSTIS GGLLARVSHT AAAEYTFILA VPMMVAASGL
210 220 230 240 250
DLIKSWDILS TADIPLFATG FITAFVVAML AIVSFLKLLS RVKLTPFAYY
260
RFILAAVFYF FIM
Length:263
Mass (Da):28,363
Last modified:April 1, 2015 - v1
Checksum:i13C6B1112878D559
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LDPG01000005 Genomic DNA Translation: KLV19082.1
LZQX01000084 Genomic DNA Translation: OJD84043.1
LZQW01000025 Genomic DNA Translation: OJD94953.1
MTAU01000005 Genomic DNA Translation: OPD59539.1
NVHS01000074 Genomic DNA Translation: PGB49492.1
RefSeqiWP_000796236.1, NZ_PPES01000002.1

Genome annotation databases

EnsemblBacteriaiANH85704; ANH85704; A8C77_07115
KLV19082; KLV19082; ABW01_10880
KEGGibanh:HYU01_07115
PATRICifig|1392.230.peg.1361

Similar proteinsi

Entry informationi

Entry nameiA0A0B5UBN1_BACAN
AccessioniPrimary (citable) accession number: A0A0B5UBN1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: May 23, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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