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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptomyces nodosus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei734ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:SNOD_11670Imported
OrganismiStreptomyces nodosusImported
Taxonomic identifieri40318 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000031526 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 175tRNA-synt_1gInterPro annotationAdd BLAST106
Domaini299 – 503tRNA-synt_1_2InterPro annotationAdd BLAST205
Domaini807 – 933Anticodon_1InterPro annotationAdd BLAST127

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi731 – 735"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0B5DHI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETNPAATA AVPAEAAPHR YTAAMAAEIE ARWQDFWDVE GTYAAPNPSG
60 70 80 90 100
DLDGAPAVVA RPKKFIMDMF PYPSGAGLHV GHPLGYIATD VFARFQRMTG
110 120 130 140 150
HNVLHTLGFD AFGLPAEQYA VQTGTHPRVS TEANIENMKS QLRRLGLGHD
160 170 180 190 200
KRRSFATIDP EYYRWTQWIF LQIYNSWYDE EAGKARPVSE LIAQFETGER
210 220 230 240 250
AVPGTGRAWH ELSAVERADV LGEYRLAYAS EAPVNWCPGL GTVLANEEVT
260 270 280 290 300
AEGRSERGNF PVFKSKLRQW NMRITAYADR LLDDLEELDW PEAIKLQQRN
310 320 330 340 350
WIGRSEGARV DFPIDGEAIT VFTTRQDTLF GATYMVLAPE HPLVEKFTPA
360 370 380 390 400
AWPEGTHEVW TGGHATPAEA VAAYRAQAAS KSDVERQAEA KDKTGVFTGA
410 420 430 440 450
YATNPVNGEK VPVFIADYVL MGYGTGAIMA VPAHDSRDFA FARAFELPMR
460 470 480 490 500
CVVEPTDGRD SDPATWDDAF ASSDAKIINS AGDDVSLDGL NVPEAKARAA
510 520 530 540 550
EWLARKGYGE GTVNFRLRDW LFSRQRYWGE PFPIVYDEDG VAHALPESML
560 570 580 590 600
PLELPEVEDY TPRTFDPDDA DTRPETPLSR NEDWVHVTLD LGDGPKKYRR
610 620 630 640 650
ETNTMPNWAG SCWYELRYLD PHNDRELVAP DIERYWMGPR EGMPHGGVDL
660 670 680 690 700
YVGGAEHAVL HLLYARFWSK VLYDLGYVSS AEPFHKLFNQ GMIQAYVYRD
710 720 730 740 750
QRGIAVPAAE VEERDGAYYH QGEKVSRVLG KMGKSLKNAV TPDEICAEYG
760 770 780 790 800
ADTLRLYEMA MGPLDVSRPW DTRAVVGQFR LLQRLWRNVV DETTGELTVV
810 820 830 840 850
DAEPDEDTLR ALHKAIDGVR QDLEGLRFNT AIAKITELNN HLTKVYGGSG
860 870 880 890 900
AAGTARRPGA VPRSIAEALV LLVAPLAPHV AEELWHRLGH GDSVVHRDFP
910 920 930 940 950
VADPAYVVDE SVTCVVQVKG KVKARLEVSP SISGEELEKV ALADEKVVAA
960 970
LGGAAVRKVI VRAPKLVNIV TG
Length:972
Mass (Da):107,705
Last modified:April 1, 2015 - v1
Checksum:i8BD837490BF2737A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009313 Genomic DNA. Translation: AJE40640.1.
RefSeqiWP_043440151.1. NZ_CP009313.1.

Genome annotation databases

EnsemblBacteriaiAJE40640; AJE40640; SNOD_11670.

Similar proteinsi

Entry informationi

Entry nameiA0A0B5DHI7_9ACTN
AccessioniPrimary (citable) accession number: A0A0B5DHI7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: March 28, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported