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Protein
Submitted name:

Alphabet, isoform F

Gene

alph

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+SAAS annotation

GO - Molecular functioni

  • magnesium ion binding Source: InterPro
  • manganese ion binding Source: InterPro
  • phosphatase activity Source: FlyBase
  • protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  • compound eye morphogenesis Source: FlyBase
  • dephosphorylation Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • dorsal closure Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • imaginal disc fusion, thorax closure Source: FlyBase
  • mitotic cell cycle Source: FlyBase
  • negative regulation of ERK1 and ERK2 cascade Source: FlyBase
  • negative regulation of JNK cascade Source: FlyBase
  • negative regulation of MAP kinase activity Source: FlyBase
  • negative regulation of Ras protein signal transduction Source: FlyBase
  • negative regulation of stress-activated MAPK cascade Source: FlyBase
  • negative regulation of stress-activated protein kinase signaling cascade Source: FlyBase
  • positive regulation of R7 cell differentiation Source: FlyBase
  • protein dephosphorylation Source: FlyBase
  • regulation of p38MAPK cascade Source: FlyBase
  • response to oxidative stress Source: FlyBase
  • response to paraquat Source: FlyBase
  • response to UV-C Source: FlyBase

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation
LigandMagnesiumSAAS annotation, Metal-bindingSAAS annotation

Enzyme and pathway databases

ReactomeiR-DME-1169408. ISG15 antiviral mechanism.
R-DME-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-DME-380972. Energy dependent regulation of mTOR by LKB1-AMPK.

Names & Taxonomyi

Protein namesi
Submitted name:
Alphabet, isoform FImported (EC:3.1.3.-Imported, EC:3.1.3.41Imported)
Gene namesi
Name:alphImported
Synonyms:Dmel\CG1906Imported, pp2c99BImported, PP2CbImported, SK3-1Imported
ORF Names:CG1906Imported, Dmel_CG1906Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0086361. alph.

Expressioni

Gene expression databases

ExpressionAtlasiA0A0B4K7Q3. differential.

Structurei

3D structure databases

SMRiA0A0B4K7Q3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 284PPM-type phosphataseInterPro annotationAdd BLAST262

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili291 – 318Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the PP2C family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0697. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00880000137909.
KOiK04461.
OMAiARVSAHC.
OrthoDBiEOG091G0AJQ.

Family and domain databases

CDDicd00143. PP2Cc. 1 hit.
Gene3Di3.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR015655. PP2C.
IPR000222. PP2C_BS.
IPR012911. PP2C_C.
IPR036457. PPM-type_dom_sf.
IPR001932. PPM-type_phosphatase_dom.
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiView protein in Pfam
PF00481. PP2C. 1 hit.
PF07830. PP2C_C. 1 hit.
SMARTiView protein in SMART
SM00332. PP2Cc. 1 hit.
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiView protein in PROSITE
PS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0B4K7Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGFLDKPKT AKHNDEGEGN KLLFGVSSMQ GWRSEMEDAY YARAGLGDAL
60 70 80 90 100
PDWSFFAVFD GHAGCKVSEH CAKHLLESII STEEFIGGDH VKGIRTGFLR
110 120 130 140 150
IDEVMRELPE FTRESEKCGG TTAVCAFVGL TQVYIANCGD SRAVLCRQGV
160 170 180 190 200
PVFATQDHKP ILPEEKERIY NAGGSVMIKR VNGTLAVSRA LGDYDFKNVK
210 220 230 240 250
EKGQCEQLVS PEPEIFCQSR QDSDEFLVLA CDGIWDVMSN EDVCSFIHSR
260 270 280 290 300
MRVTSNLVSI ANQVVDTCLH KGSRDNMSII IIAFPGAPKP TEEAIEAEHR
310 320 330
LEKQIEKITR ERELAEWANC QCKNKKQKAI QI
Length:332
Mass (Da):36,941
Last modified:April 1, 2015 - v1
Checksum:iA7FA94305F0C2D3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AFH06673.1.
RefSeqiNP_001247356.1. NM_001260427.2.
UniGeneiDm.7085.

Genome annotation databases

EnsemblMetazoaiFBtr0309241; FBpp0301180; FBgn0086361.
GeneIDi43481.
KEGGidme:Dmel_CG1906.

Similar proteinsi

Entry informationi

Entry nameiA0A0B4K7Q3_DROME
AccessioniPrimary (citable) accession number: A0A0B4K7Q3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: March 28, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported