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Protein
Submitted name:

Voltage-dependent T-type calcium channel subunit alpha-1G

Gene

CACNA1G

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent T-type calcium channel subunit alpha-1GImported
Gene namesi
Name:CACNA1GImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000006283.17.
HGNCiHGNC:1394. CACNA1G.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei214 – 237HelicalSequence analysisAdd BLAST24
Transmembranei342 – 363HelicalSequence analysisAdd BLAST22
Transmembranei369 – 394HelicalSequence analysisAdd BLAST26
Transmembranei744 – 762HelicalSequence analysisAdd BLAST19
Transmembranei774 – 795HelicalSequence analysisAdd BLAST22
Transmembranei865 – 884HelicalSequence analysisAdd BLAST20
Transmembranei941 – 964HelicalSequence analysisAdd BLAST24
Transmembranei1277 – 1295HelicalSequence analysisAdd BLAST19
Transmembranei1315 – 1336HelicalSequence analysisAdd BLAST22
Transmembranei1348 – 1367HelicalSequence analysisAdd BLAST20
Transmembranei1412 – 1434HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000006283.

PTM / Processingi

Proteomic databases

PaxDbiA0A0B4J1X2.
PeptideAtlasiA0A0B4J1X2.

Expressioni

Gene expression databases

BgeeiENSG00000006283.
ExpressionAtlasiA0A0B4J1X2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A0B4J1X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 405Ion_transInterPro annotationAdd BLAST326
Domaini743 – 969Ion_transInterPro annotationAdd BLAST227
Domaini1275 – 1474Ion_transInterPro annotationAdd BLAST200

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128242.

Family and domain databases

InterProiView protein in InterPro
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR030154. VDCC_T_a1G.
PANTHERiPTHR10037:SF137. PTHR10037:SF137. 1 hit.
PfamiView protein in Pfam
PF00520. Ion_trans. 3 hits.
PRINTSiPR01629. TVDCCALPHA1.

Sequencei

Sequence statusi: Complete.

A0A0B4J1X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG
60 70 80 90 100
LPYPALAPVV FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM
110 120 130 140 150
FRPCEDIACD SQRCRILQAF DDFIFAFFAV EMVVKMVALG IFGKKCYLGD
160 170 180 190 200
TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR TVRVLRPLRA INRVPSMRIL
210 220 230 240 250
VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR CFLPENFSLP
260 270 280 290 300
LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL
310 320 330 340 350
DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV
360 370 380 390 400
ITLEGWVDIM YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE
410 420 430 440 450
TKQRESQLMR EQRVRFLSNA STLASFSEPG SCYEELLKYL VYILRKAARR
460 470 480 490 500
LAQVSRAAGV RVGLLSSPAP LGGQETQPSS SCSRSHRRLS VHHLVHHHHH
510 520 530 540 550
HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP ALSGAPPGGA
560 570 580 590 600
ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE
610 620 630 640 650
TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI
660 670 680 690 700
SSPCLKADSG ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA
710 720 730 740 750
QHSDLRDPHS RRQRSLGPDA EPSSVLAFWR LICDTFRKIV DSKYFGRGIM
760 770 780 790 800
IAILVNTLSM GIEYHEQPEE LTNALEISNI VFTSLFALEM LLKLLVYGPF
810 820 830 840 850
GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR VLKLVRFLPA
860 870 880 890 900
LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL
910 920 930 940 950
PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF
960 970 980 990 1000
GNYVLFNLLV AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE
1010 1020 1030 1040 1050
SEPDFFSPSL DGDGDRKKCL ALVSLGEHPE LRKSLLPPLI IHTAATPMSL
1060 1070 1080 1090 1100
PKSTSTGLGE ALGPASRRTS SSGSAEPGAA HEMKSPPSAR SSPHSPWSAA
1110 1120 1130 1140 1150
SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ DEEESSEEER
1160 1170 1180 1190 1200
ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN
1210 1220 1230 1240 1250
GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE
1260 1270 1280 1290 1300
RDSWSAYIFP PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI
1310 1320 1330 1340 1350
DPHSAERIFL TLSNYIFTAV FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD
1360 1370 1380 1390 1400
GLLVLISVID ILVSMVSDSG TKILGMLRVL RLLRTLRPLR VISRAQGLKL
1410 1420 1430 1440 1450
VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV CQGEDTRNIT
1460 1470 1480 1490 1500
NKSDCAEASY RWVRHKYNFD NLGQVSPRLR GGAVVKEAGG GTGPCLVIPA
1510 1520 1530 1540 1550
DSGGGGLHEE ISPSHPLLSN HQHVAKPSPS HSAPKSGPMG SLAVLKDEET

EAQRG
Length:1,555
Mass (Da):171,386
Last modified:March 4, 2015 - v1
Checksum:i1219B12AD46561AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004590 Genomic DNA. No translation available.
AC021491 Genomic DNA. No translation available.
UniGeneiHs.591169.

Genome annotation databases

EnsembliENST00000416767; ENSP00000392390; ENSG00000006283.

Similar proteinsi

Entry informationi

Entry nameiA0A0B4J1X2_HUMAN
AccessioniPrimary (citable) accession number: A0A0B4J1X2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 4, 2015
Last sequence update: March 4, 2015
Last modified: October 25, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported