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Protein

Methionine aminopeptidase

Gene

map

Organism
Archaeon GW2011_AR5
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65SubstrateUniRule annotation1
Metal bindingi85Divalent metal cation 1UniRule annotation1
Metal bindingi96Divalent metal cation 1UniRule annotation1
Metal bindingi96Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi155Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
Binding sitei163SubstrateUniRule annotation1
Metal bindingi188Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi288Divalent metal cation 1UniRule annotation1
Metal bindingi288Divalent metal cation 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotationImported, Hydrolase, Protease
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidaseUniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAPUniRule annotation
Short name:
MetAPUniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
Name:mapUniRule annotation
ORF Names:QT00_C0002G0055Imported
OrganismiArchaeon GW2011_AR5Imported
Taxonomic identifieri1579367 [NCBI]
Taxonomic lineageiArchaea

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 294Peptidase_M24InterPro annotationAdd BLAST287

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.UniRule annotation

Family and domain databases

Gene3Di1.10.10.101 hit
HAMAPiMF_01975 MetAP_2_arc, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR028595 MetAP_archaeal
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002468 Pept_M24A_MAP2
IPR018349 Pept_M24A_MAP2_BS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF46785 SSF46785, 1 hit
SSF55920 SSF55920, 2 hits
TIGRFAMsiTIGR00501 met_pdase_II, 1 hit
PROSITEiView protein in PROSITE
PS01202 MAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0B3A501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDEVLEKYI KAGKIAAEVR EASAKLAKVG MPLLELAETV ESMVRERGAE
60 70 80 90 100
PAFPVNLSLN EFAAHYTPQH NDETKISEGD VLKIDVGAHI DGYIADTAIT
110 120 130 140 150
VDFGNHAALL KATKDALAAA VGVVKIGAAI GDISRAIDET IRASGFVPVE
160 170 180 190 200
NLTGHGLDQY VEHKEPSIPN ISLRNDTKLT EDQVIAIEPF ATGGAGHVKD
210 220 230 240 250
SPEVMIFSFS ADKPVRGVDA KKIVSFVQRY NGLPFAERWL MTEQAQNAGV
260 270 280 290 300
PNSLFKVRLA LRELVQRGVL YSYPVLREAK AGMVSQAEHT VIVRDEPIII

TK
Length:302
Mass (Da):32,764
Last modified:March 4, 2015 - v1
Checksum:iF3A9ABE182D173B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JWKQ01000002 Genomic DNA Translation: KHO47403.1

Genome annotation databases

PATRICifig|1579367.3.peg.589

Similar proteinsi

Entry informationi

Entry nameiA0A0B3A501_ARCGX
AccessioniPrimary (citable) accession number: A0A0B3A501
Entry historyiIntegrated into UniProtKB/TrEMBL: March 4, 2015
Last sequence update: March 4, 2015
Last modified: April 25, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)