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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borreliella chilensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei620ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:OY14_01240Imported
OrganismiBorreliella chilensisImported
Taxonomic identifieri1245910 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000030940 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 177tRNA-synt_1gInterPro annotationAdd BLAST135
Domaini227 – 410tRNA-synt_1_2InterPro annotationAdd BLAST184
Domaini424 – 579tRNA-synt_1InterPro annotationAdd BLAST156
Domaini617 – 643tRNA-synt_1InterPro annotationAdd BLAST27
Domaini686 – 816Anticodon_1InterPro annotationAdd BLAST131

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi617 – 621"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

KOiK01869

Family and domain databases

Gene3Di3.40.50.6202 hits
3.90.740.101 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0A7UV04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKYEFKKIE KKWQEFWDNN KTYKVEEDPS IPKEKRLYIL DMFPYPSANG
60 70 80 90 100
LHVGHPEGYT ATDIFGRYKL LNGFHVLHPI GFDSFGLPAE NYAIQTGTHP
110 120 130 140 150
QKSTEENINK FKKQIKALGF AYDWDREIRT HDETYYKWTQ WIFLQLYKKG
160 170 180 190 200
LAYAKEMPVW YCPELGTVLA NEEIIQTPDG PKSERGFHNV EKKYLRQWVL
210 220 230 240 250
KITEYAERLL NDLEELEWPE SVKEMQRNWI GKSTGVEIDF EIEGYNDKVT
260 270 280 290 300
VFTTRPDTIF GVTYLVIAPE NKITEKITKN NFKNNVLKYI KNEELKSDLE
310 320 330 340 350
RTSLEKDKSG IFTGSYAFHP ITNEKIPIWV GSYVLGAYGT GAVMGVPAHD
360 370 380 390 400
ERDFQFAKKY KLKILSVISK SGKNEPLEKA FTNDGISINS PNEFNNLKNS
410 420 430 440 450
EVKDKVIKWL TKNKKGKEKV NYKLRDWIFS RQRYWGEPIP ILFDKLGNAI
460 470 480 490 500
PLEKNDLPLK LPEIANYKPS GTGESPLSRI KDWVNIKDTD FTRETNTMPQ
510 520 530 540 550
WAGSCWYYLR YLDPKNQKEF ASKKNIEYWM PVDLYIGGAE HTVLHLLYSR
560 570 580 590 600
FWHKVLYDLG YVNTKEPFKK LINQGIITSF SYQKENGILI PNDQVIEKDN
610 620 630 640 650
KFFDKKDNQE VTQVIAKMSK SLKNVIAPDD IIKEFGADSI RVYEMFMGPL
660 670 680 690 700
TDSKPWSTKG IVGVFRFLNK IWNLREKELS KDNPPKEITS QLHKVIKKVT
710 720 730 740 750
EDTENLNFNT AISAMMIFIN KLLKYEKNYL NIFKPFIIIL SPYAPHLAEE
760 770 780 790 800
LWEHIGEPPS LFKNSKWPKF DENLIIKDTK EIVLQINGKI KDKILLDKEI
810 820 830 840
DEEELKKIAM ENRKIKSHLL NKKIVKIIAI KNKLVNIVIK
Length:840
Mass (Da):98,235
Last modified:March 4, 2015 - v1
Checksum:i45ED34BDD5B4BE3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009910 Genomic DNA Translation: AJA90081.1

Genome annotation databases

EnsemblBacteriaiAJA90081; AJA90081; OY14_01240
KEGGibchi:OY14_01240

Similar proteinsi

Entry informationi

Entry nameiA0A0A7UV04_9SPIR
AccessioniPrimary (citable) accession number: A0A0A7UV04
Entry historyiIntegrated into UniProtKB/TrEMBL: March 4, 2015
Last sequence update: March 4, 2015
Last modified: March 28, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported