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Protein

Allantoinase

Gene

allB

Organism
Bacillus subtilis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes allantoate from (S)-allantoin.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Allantoinase (allB), Allantoinase (allB), Allantoinase (allB), Allantoinase (allB), Allantoinase (allB), Allantoinase (allB), Allantoinase (allB), Allantoinase (allB), Allantoinase (allB), Allantoinase (allB)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes allantoate from (S)-allantoin, the pathway (S)-allantoin degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc 1UniRule annotation1
Metal bindingi62Zinc 1UniRule annotation1
Metal bindingi147Zinc 1; via carbamate groupUniRule annotation1
Metal bindingi147Zinc 2; via carbamate groupUniRule annotation1
Metal bindingi183Zinc 2UniRule annotation1
Metal bindingi239Zinc 2UniRule annotation1
Metal bindingi312Zinc 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processPurine metabolismUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Synonyms:pucHUniRule annotation
ORF Names:KS08_16135Imported
OrganismiBacillus subtilisImported
Taxonomic identifieri1423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000030075 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A0A0TTB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 426Amidohydro-relInterPro annotationAdd BLAST376

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.UniRule annotation

Family and domain databases

Gene3Di2.30.40.10, 3 hits
HAMAPiMF_01645 Hydantoinase, 1 hit
InterProiView protein in InterPro
IPR017593 Allantoinase
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR03178 allantoinase, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0A0TTB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYDVIVKGA KAVRKGGTKQ ADIAVKDGKI AMIGPGIDEK AEQVVQADGM
60 70 80 90 100
YVFPGAVDCH VHFNEPGREE WEGIETGSKM LAAGGCTAYF DMPLNCIPST
110 120 130 140 150
VTAENLLAKA EIASRKSAVD FALWGGLMPG YTEHIRPMAE AGAIGFKAFL
160 170 180 190 200
SKSGTDEFQS ADERTLLKGM KEIAACGKIL ALHAESDALT RFLGAEYALQ
210 220 230 240 250
GKIDARAYTS SRPEEAECEA VQRAIEYAKV TGCALHFVHI STKRAVMSIQ
260 270 280 290 300
QAKKDGMDVT VETCPHYLLF SFEDFLKKGS AAKCAPPLRS EADKEELIGV
310 320 330 340 350
LAEGLIDMVS SDHSPCHPSL KREDNMFLSW GGISGGQFTL LGMIQLAIEH
360 370 380 390 400
RLPFEHVARW TAEAPAKRFG LMNKGRLEAG FDADFVIVRP ESFTVTKETM
410 420 430 440 450
FSRHKQSLYE GHTFPYRIAA TYSKGRCVYQ DDGDKESGAF GTFLKPTEMK

EPIL
Length:454
Mass (Da):49,591
Last modified:February 4, 2015 - v1
Checksum:iD27D29497434C041
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009748 Genomic DNA Translation: AIW35089.1
RefSeqiWP_013353463.1, NZ_CP009748.1

Genome annotation databases

EnsemblBacteriaiAIW35089; AIW35089; KS08_16135
GeneIDi9781638

Similar proteinsi

Entry informationi

Entry nameiA0A0A0TTB6_BACIU
AccessioniPrimary (citable) accession number: A0A0A0TTB6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 4, 2015
Last sequence update: February 4, 2015
Last modified: February 28, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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