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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Bacillus subtilis
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei595For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
ORF Names:KS08_01040Imported
OrganismiBacillus subtilisImported
Taxonomic identifieri1423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000030075 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 217Glutamine amidotransferase type-2InterPro annotationAdd BLAST216
Domaini283 – 422SISInterPro annotationAdd BLAST140
Domaini452 – 590SISInterPro annotationAdd BLAST139

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0A0A0TLH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYIGH LDAKEILLKG LEKLEYRGYD SAGIAVANEQ GVHVYKEKGR
60 70 80 90 100
IADLREVVDQ TVESQAGIGH TRWATHGEPS FLNAHPHQSA LGRFTLVHNG
110 120 130 140 150
VIENYVQLKR EYLENVELKS DTDTEVVVQM IEQFVAGGLS TEEAFRKTLT
160 170 180 190 200
LLKGSYAIAL FDGENTDTIY VAKNKSPLLI GLGDTFNVVA SDAMAMLQVT
210 220 230 240 250
NEYVELLDKE MVIVTKDEAV IKNLDGEVMT RASYIAELDA SDIEKGTYPH
260 270 280 290 300
YMLKETDEQP LVMRKIIQTY QDENGRLAVA GDVADAVAEA DRIYIVACGT
310 320 330 340 350
SYHAGLVGKQ YIEMWANVPV EVHVASEFSY NMPLLSKKPL FIFLSQSGET
360 370 380 390 400
ADSRAVLVQV KALGHKALTI TNVPGSTLSR EADYTLLLHA GPEIAVASTK
410 420 430 440 450
AYTAQIAVLA ILASVAAERN GVDIGFDLVK ELGIAANAME ALCDQKDEME
460 470 480 490 500
MIAREYLTVS RNAFFIGRGL DYFVCVEGAL KLKEISYIQA EGFAGGELKH
510 520 530 540 550
GTIALIEEGT PVFALATQEH VNLSIRGNVK EVAARGANTC IISLKGLEDA
560 570 580 590 600
DDRFVLPEVN PALAPLVSVV PLQLIAYYAA LHRGCDVDKP RNLAKSVTVE
Length:600
Mass (Da):65,374
Last modified:February 4, 2015 - v1
Checksum:i90AC4331AF182174
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009748 Genomic DNA. Translation: AIW32296.1.
RefSeqiWP_013350854.1. NZ_CP009748.1.

Genome annotation databases

EnsemblBacteriaiAIW32296; AIW32296; KS08_01040.
GeneIDi9778906.

Similar proteinsi

Entry informationi

Entry nameiA0A0A0TLH4_BACIU
AccessioniPrimary (citable) accession number: A0A0A0TLH4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 4, 2015
Last sequence update: February 4, 2015
Last modified: November 22, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported