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Protein
Submitted name:

Transcription factor 7-like 2

Gene

TCF7L2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi293 – 361HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor 7-like 2Imported
Gene namesi
Name:TCF7L2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148737.15
HGNCiHGNC:11641 TCF7L2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148737

PTM / Processingi

Proteomic databases

MaxQBiA0A0A0MTL7
PeptideAtlasiA0A0A0MTL7

Expressioni

Gene expression databases

BgeeiENSG00000148737
ExpressionAtlasiA0A0A0MTL7 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MTL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini293 – 361HMG boxInterPro annotationAdd BLAST69

Phylogenomic databases

GeneTreeiENSGT00390000009964

Family and domain databases

Gene3Di1.10.30.10, 1 hit
4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR027397 Catenin_binding_dom_sf
IPR013558 CTNNB1-bd_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF
IPR028773 TCF7L
PANTHERiPTHR10373 PTHR10373, 2 hits
PTHR10373:SF25 PTHR10373:SF25, 2 hits
PfamiView protein in Pfam
PF08347 CTNNB1_binding, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0A0MTL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN
60 70 80 90 100
ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY
110 120 130 140 150
PGYPFIMIPD LTSPYLPNGS LSPTARTSNK VPVVQHPHHV HPLTPLITYS
160 170 180 190 200
NEHFTPGNPP PHLPADVDPK TGIPRPPHPP DISPYYPLSP GTVGQIPHPL
210 220 230 240 250
GWLVPQQGQP VYPITTGGFR HPYPTALTVN ASMSRFPPHM VPPHHTLHTT
260 270 280 290 300
GIPHPAIVTP TVKQESSQSD VGSLHSSKHQ DSKKEEEKKK PHIKKPLNAF
310 320 330 340 350
MLYMKEMRAK VVAECTLKES AAINQILGRR WHALSREEQA KYYELARKER
360 370 380 390 400
QLHMQLYPGW SARDNYGKKK KRKRDKQPGE TNGEKKSAFA TYKVKAAASA

HPLQMEAY
Length:408
Mass (Da):45,379
Last modified:January 7, 2015 - v1
Checksum:i3C90E20FE560586F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135792 Genomic DNA No translation available.
AL158212 Genomic DNA No translation available.
AL445486 Genomic DNA No translation available.
AL451084 Genomic DNA No translation available.
RefSeqiNP_001185459.1, NM_001198530.1
UniGeneiHs.593995

Genome annotation databases

EnsembliENST00000534894; ENSP00000443626; ENSG00000148737
GeneIDi6934
UCSCiuc010qrn.3 human

Similar proteinsi

Entry informationi

Entry nameiA0A0A0MTL7_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MTL7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: May 23, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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