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Protein
Submitted name:

Potassium voltage-gated channel subfamily KQT member 5

Gene

KCNQ5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel subfamily KQT member 5Imported
Gene namesi
Name:KCNQ5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000185760.15.
HGNCiHGNC:6299. KCNQ5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei127 – 149HelicalSequence analysisAdd BLAST23
Transmembranei155 – 180HelicalSequence analysisAdd BLAST26
Transmembranei201 – 219HelicalSequence analysisAdd BLAST19
Transmembranei269 – 287HelicalSequence analysisAdd BLAST19
Transmembranei326 – 352HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185760.

PTM / Processingi

Proteomic databases

PaxDbiA0A0A0MSD9.

Expressioni

Gene expression databases

BgeeiENSG00000185760.
ExpressionAtlasiA0A0A0MSD9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MSD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 352Ion_transInterPro annotationAdd BLAST223
Domaini457 – 644KCNQ_channelInterPro annotationAdd BLAST188

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1419. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00550000074513.

Family and domain databases

InterProiView protein in InterPro
IPR005821. Ion_trans_dom.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiView protein in Pfam
PF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
PRINTSiPR00169. KCHANNEL.
PR01459. KCNQCHANNEL.

Sequencei

Sequence statusi: Complete.

A0A0A0MSD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRHHAGGEE GGAAGLWVKS GAAAAAAGGG RLGSGMKDVE SGRGRVLLNS
60 70 80 90 100
AAARGDGLLL LGTRAATLGG GGGGLRESRR GKQGARMSLL GKPLSYTSSQ
110 120 130 140 150
SCRRNVKYRR VQNYLYNVLE RPRGWAFIYH AFVFLPVFGC LILSVFSTIP
160 170 180 190 200
EHTKLASSCL LILEFVMIVV FGLEFIIRIW SAGCCCRYRG WQGRLRFARK
210 220 230 240 250
PFCVIDTIVL IASIAVVSAK TQGNIFATSA LRSLRFLQIL RMVRMDRRGG
260 270 280 290 300
TWKLLGSVVY AHSKELITAW YIGFLVLIFS SFLVYLVEKD ANKEFSTYAD
310 320 330 340 350
ALWWGTITLT TIGYGDKTPL TWLGRLLSAG FALLGISFFA LPAGILGSGF
360 370 380 390 400
ALKVQEQHRQ KHFEKRRNPA ANLIQCVWRS YAADEKSVSI ATWKPHLKAL
410 420 430 440 450
HTCSPTNKFC SNKQKLFRMY TSRKQSQKLS FKERVRMASP RGQSIKSRQA
460 470 480 490 500
SVGDRRSPST DITAEGSPTK VQKSWSFNDR TRFRPSLRLK SSQPKPVIDA
510 520 530 540 550
DTALGTDDVY DEKGCQCDVS VEDLTPPLKT VIRAIRIMKF HVAKRKFKET
560 570 580 590 600
LRPYDVKDVI EQYSAGHLDM LCRIKSLQTR VDQILGKGQI TSDKKSREKI
610 620 630 640 650
TAEHETTDDL SMLGRVVKVE KQVQSIESKL DCLLDIYQQV LRKGSASALA
660 670 680 690 700
LASFQIPPFE CEQTSDYQSP VDSKDLSGSA QNSGCLSRST SANISRGLQF
710 720 730 740 750
ILTPNEFSAQ TFYALSPTMH SQATQVPISQ SDGSAVAATN TIANQINTAP
760 770 780 790 800
KPAAPTTLQI PPPLPAIKHL PRPETLHPNP AGLQESISDV TTCLVASKEN
810 820 830 840 850
VQVAQSNLTK DRSMRKSFDM GGETLLSVCP MVPKDLGKSL SVQNLIRSTE
860 870 880 890 900
ELNIQLSGSE SSGSRGSQDF YPKWRESKLF ITDEEVGPEE TETDTFDAAP
910 920 930 940
QPAREAAFAS DSLRTGRSRS SQSICKAGES TDALSLPHVK LK
Length:942
Mass (Da):103,608
Last modified:January 7, 2015 - v1
Checksum:i8673E7B609A9442E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049845 Genomic DNA. No translation available.
AL360232 Genomic DNA. No translation available.
AL360236 Genomic DNA. No translation available.
AL513522 Genomic DNA. No translation available.
AL671823 Genomic DNA. No translation available.
FO393414 Genomic DNA. No translation available.
KF458205 Genomic DNA. No translation available.
KF510958 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000402622; ENSP00000385501; ENSG00000185760.
UCSCiuc063png.1. human.

Similar proteinsi

Entry informationi

Entry nameiA0A0A0MSD9_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MSD9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: September 27, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported