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Protein
Submitted name:

Caspase-7

Gene

CASP7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase-7Imported
Gene namesi
Name:CASP7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165806.19
HGNCiHGNC:1508 CASP7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165806

PTM / Processingi

Proteomic databases

EPDiA0A0A0MRL7
PeptideAtlasiA0A0A0MRL7

Expressioni

Gene expression databases

BgeeiENSG00000165806
ExpressionAtlasiA0A0A0MRL7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MRL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 275CASPASE_P20InterPro annotationAdd BLAST125
Domaini294 – 388CASPASE_P10InterPro annotationAdd BLAST95

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00760000118912
OMAiSGSWFVQ
OrthoDBiEOG091G05YD

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00115 CASc, 1 hit
SUPFAMiSSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0A0MRL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAGTRVALG SSTPAERTTP SQGRCKPRPA LPRAAPPSAA PRLLVSLSLK
60 70 80 90 100
GPQTLAAERR RETVPVPAAL PPWERWQMIR AVLKSRGLRI QQMKIQWMLS
110 120 130 140 150
QTGPRLYRPS SAPDSGTLYF TSKKKKNVTM RSIKTTRDRV PTYQYNMNFE
160 170 180 190 200
KLGKCIIINN KNFDKVTGMG VRNGTDKDAE ALFKCFRSLG FDVIVYNDCS
210 220 230 240 250
CAKMQDLLKK ASEEDHTNAA CFACILLSHG EENVIYGKDG VTPIKDLTAH
260 270 280 290 300
FRGDRCKTLL EKPKLFFIQA CRGTELDDGI QADSGPINDT DANPRYKIPV
310 320 330 340 350
EADFLFAYST VPGYYSWRSP GRGSWFVQAL CSILEEHGKD LEIMQILTRV
360 370 380
NDRVARHFES QSDDPHFHEK KQIPCVVSML TKELYFSQ
Length:388
Mass (Da):43,728
Last modified:January 7, 2015 - v1
Checksum:i9F53F2E039587105
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592546 Genomic DNA No translation available.
AL627395 Genomic DNA No translation available.
RefSeqiNP_001253986.1, NM_001267057.1
UniGeneiHs.9216

Genome annotation databases

EnsembliENST00000369321; ENSP00000358327; ENSG00000165806
GeneIDi840
UCSCiuc010qsa.4 human

Similar proteinsi

Entry informationi

Entry nameiA0A0A0MRL7_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MRL7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: May 23, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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