Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Gamma-aminobutyric acid receptor subunit gamma-3

Gene

GABRG3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Gamma-aminobutyric acid receptor subunit gamma-3Imported
Gene namesi
Name:GABRG3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000182256.12.
HGNCiHGNC:4088. GABRG3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei74 – 98HelicalSequence analysisAdd BLAST25
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei131 – 153HelicalSequence analysisAdd BLAST23
Transmembranei268 – 287HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182256.

PTM / Processingi

Proteomic databases

PaxDbiA0A0A0MR73.
PRIDEiA0A0A0MR73.

Expressioni

Gene expression databases

BgeeiENSG00000182256.
ExpressionAtlasiA0A0A0MR73. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MR73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 74Neur_chan_LBDInterPro annotationAdd BLAST74
Domaini81 – 282Neur_chan_membInterPro annotationAdd BLAST202

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.

Family and domain databases

Gene3Di1.20.58.390. 1 hit.
2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006028. GABAA/Glycine_rcpt.
IPR005440. GABBAg3_rcpt.
IPR005437. GABBAg_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR036734. Neur_chan_lig-bd_sf.
IPR006201. Neur_channel.
IPR036719. Neuro-gated_channel_TM_sf.
IPR006029. Neurotrans-gated_channel_TM.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
PRINTSiPR00253. GABAARECEPTR.
PR01620. GABAARGAMMA.
PR01623. GABAARGAMMA3.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0A0MR73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEHSCPLIF SSYGYPKEEM IYRWRKNSVE AADQKSWRLY QFDFMGLRNT
60 70 80 90 100
TEIVTTSAGD YVVMTIYFEL SRRMGYFTIQ TYIPCILTVV LSWVSFWIKK
110 120 130 140 150
DATPARTALG ITTVLTMTTL STIARKSLPR VSYVTAMDLF VTVCFLFVFA
160 170 180 190 200
ALMEYATLNY YSSCRKPTTT KKTTSLLHPD SSRWIPERIS LQAPSNYSLL
210 220 230 240 250
DMRPPPTAMI TLNNSVYWQE FEDTCVYECL DGKDCQSFFC CYEECKSGSW
260 270 280
RKGRIHIDIL ELDSYSRVFF PTSFLLFNLV YWVGYLYL
Length:288
Mass (Da):33,582
Last modified:January 7, 2015 - v1
Checksum:i636D6B7AF7698428
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127511 Genomic DNA. No translation available.
AC135326 Genomic DNA. No translation available.
AC136896 Genomic DNA. No translation available.
AC144833 Genomic DNA. No translation available.
AC145436 Genomic DNA. No translation available.
EU606049 Genomic DNA. No translation available.
KC877538 Genomic DNA. No translation available.
KF511214 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000333743; ENSP00000331912; ENSG00000182256.
UCSCiuc059gxz.1. human.

Similar proteinsi

Entry informationi

Entry nameiA0A0A0MR73_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MR73
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: October 25, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported