Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Laminin subunit alpha-4

Gene

LAMA4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Laminin subunit alpha-4Imported
Gene namesi
Name:LAMA4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112769.18.
HGNCiHGNC:6484. LAMA4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000112769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500197439228 – 1823Sequence analysisAdd BLAST1796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi101 ↔ 110PROSITE-ProRule annotation
Disulfide bondi157 ↔ 166PROSITE-ProRule annotation
Disulfide bondi212 ↔ 221PROSITE-ProRule annotation
Disulfide bondi224 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiA0A0A0MQS9.
PeptideAtlasiA0A0A0MQS9.
PRIDEiA0A0A0MQS9.

Expressioni

Gene expression databases

BgeeiENSG00000112769.
ExpressionAtlasiA0A0A0MQS9. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MQS9.
SMRiA0A0A0MQS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 131Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini132 – 186Laminin EGF-likeInterPro annotationAdd BLAST55
Domaini187 – 240Laminin EGF-likeInterPro annotationAdd BLAST54
Domaini833 – 1035LAM_G_DOMAINInterPro annotationAdd BLAST203
Domaini1047 – 1227LAM_G_DOMAINInterPro annotationAdd BLAST181
Domaini1234 – 1402LAM_G_DOMAINInterPro annotationAdd BLAST169
Domaini1469 – 1640LAM_G_DOMAINInterPro annotationAdd BLAST172
Domaini1647 – 1820LAM_G_DOMAINInterPro annotationAdd BLAST174

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili339 – 366Sequence analysisAdd BLAST28
Coiled coili381 – 401Sequence analysisAdd BLAST21
Coiled coili478 – 505Sequence analysisAdd BLAST28
Coiled coili587 – 614Sequence analysisAdd BLAST28
Coiled coili666 – 689Sequence analysisAdd BLAST24
Coiled coili785 – 805Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IP6G. Eukaryota.
ENOG410Z3D5. LUCA.
GeneTreeiENSGT00780000121851.
KOiK06241.
OMAiQVSMMFD.
OrthoDBiEOG091G005L.

Family and domain databases

InterProiView protein in InterPro
IPR013320. ConA-like_dom_sf.
IPR000742. EGF-like_dom.
IPR009254. Laminin_aI.
IPR010307. Laminin_domII.
IPR002049. Laminin_EGF.
IPR001791. Laminin_G.
PfamiView protein in Pfam
PF00053. Laminin_EGF. 3 hits.
PF02210. Laminin_G_2. 5 hits.
PF06008. Laminin_I. 1 hit.
PF06009. Laminin_II. 1 hit.
SMARTiView protein in SMART
SM00181. EGF. 3 hits.
SM00180. EGF_Lam. 3 hits.
SM00282. LamG. 5 hits.
SUPFAMiSSF49899. SSF49899. 5 hits.
PROSITEiView protein in PROSITE
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 3 hits.
PS50025. LAM_G_DOMAIN. 5 hits.

Sequencei

Sequence statusi: Complete.

A0A0A0MQS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSSAWRSV LPLWLLWSAA CSRAASGDDN AFPFDIEGSS AVGRQDPPET
60 70 80 90 100
SEPRVALGRL PPAAEKCNAG FFHTLSGECV PCDCNGNSNE CLDGSGYCVH
110 120 130 140 150
CQRNTTGEHC EKCLDGYIGD SIRGAPQFCQ PCPCPLPHLA NFAESCYRKN
160 170 180 190 200
GAVRCICNEN YAGPNCERCA PGYYGNPLLI GSTCKKCDCS GNSDPNLIFE
210 220 230 240 250
DCDEVTGQCR NCLRNTTGFK CERCAPGYYG DARIAKNCAV CNCGGGPCDS
260 270 280 290 300
VTGECLEEGF EPPTGMDCPT ISCDKCVWDL TDDLRLAALS IEEGKSGVLS
310 320 330 340 350
VSSGAAAHRH VNEINATIYL LKTKLSEREN QYALRKIQIN NAENTMKSLL
360 370 380 390 400
SDVEELVEKE NQASRKGQLV QKESMDTINH ASQLVEQAHD MRDKIQEINN
410 420 430 440 450
KMLYYGEEHE LSPKEISEKL VLAQKMLEEI RSRQPFFTQR ELVDEEADEA
460 470 480 490 500
YELLSQAESW QRLHNETRTL FPVVLEQLDD YNAKLSDLQE ALDQALNYVR
510 520 530 540 550
DAEDMNRATA ARQRDHEKQQ ERVREQMEVV NMSLSTSADS LTTPRLTLSE
560 570 580 590 600
LDDIIKNASG IYAEIDGAKS ELQVKLSNLS NLSHDLVQEA IDHAQDLQQE
610 620 630 640 650
ANELSRKLHS SDMNGLVQKA LDASNVYENI VNYVSEANET AEFALNTTDR
660 670 680 690 700
IYDAVSGIDT QIIYHKDESE NLLNQARELQ AKAESSSDEA VADTSRRVGG
710 720 730 740 750
ALARKSALKT RLSDAVKQLQ AAERGDAQQR LGQSRLITEE ANRTTMEVQQ
760 770 780 790 800
ATAPMANNLT NWSQNLQHFD SSAYNTAVNS ARDAVRNLTE VVPQLLDQLR
810 820 830 840 850
TVEQKRPASN VSASIQRIRE LIAQTRSVAS KIQVSMMFDG QSAVEVHSRT
860 870 880 890 900
SMDDLKAFTS LSLYMKPPVK RPELTETADQ FILYLGSKNA KKEYMGLAIK
910 920 930 940 950
NDNLVYVYNL GTKDVEIPLD SKPVSSWPAY FSIVKIERVG KHGKVFLTVP
960 970 980 990 1000
SLSSTAEEKF IKKGEFSGDD SLLDLDPEDT VFYVGGVPSN FKLPTSLNLP
1010 1020 1030 1040 1050
GFVGCLELAT LNNDVISLYN FKHIYNMDPS TSVPCARDKL AFTQSRAASY
1060 1070 1080 1090 1100
FFDGSGYAVV RDITRRGKFG QVTRFDIEVR TPADNGLILL MVNGSMFFRL
1110 1120 1130 1140 1150
EMRNGYLHVF YDFGFSGGPV HLEDTLKKAQ INDAKYHEIS IIYHNDKKMI
1160 1170 1180 1190 1200
LVVDRRHVKS MDNEKMKIPF TDIYIGGAPP EILQSRALRA HLPLDINFRG
1210 1220 1230 1240 1250
CMKGFQFQKK DFNLLEQTET LGVGYGCPED SLISRRAYFN GQSFIASIQK
1260 1270 1280 1290 1300
ISFFDGFEGG FNFRTLQPNG LLFYYASGSD VFSISLDNGT VIMDVKGIKV
1310 1320 1330 1340 1350
QSVDKQYNDG LSHFVISSVS PTRYELIVDK SRVGSKNPTK GKIEQTQASE
1360 1370 1380 1390 1400
KKFYFGGSPI SAQYANFTGC ISNAYFTRVD RDVEVEDFQR YTEKVHTSLY
1410 1420 1430 1440 1450
ECPIESSPLF LLHKKGKNLS KPKASQNKKG GKSKDAPSWD PVALKLPERN
1460 1470 1480 1490 1500
TPRNSHCHLS NSPRAIEHAY QYGGTANSRQ EFEHLKGDFG AKSQFSIRLR
1510 1520 1530 1540 1550
TRSSHGMIFY VSDQEENDFM TLFLAHGRLV YMFNVGHKKL KIRSQEKYND
1560 1570 1580 1590 1600
GLWHDVIFIR ERSSGRLVID GLRVLEESLP PTEATWKIKG PIYLGGVAPG
1610 1620 1630 1640 1650
KAVKNVQINS IYSFSGCLSN LQLNGASITS ASQTFSVTPC FEGPMETGTY
1660 1670 1680 1690 1700
FSTEGGYVVL DESFNIGLKF EIAFEVRPRS SSGTLVHGHS VNGEYLNVHM
1710 1720 1730 1740 1750
KNGQVIVKVN NGIRDFSTSV TPKQSLCDGR WHRITVIRDS NVVQLDVDSE
1760 1770 1780 1790 1800
VNHVVGPLNP KPIDHREPVF VGGVPESLLT PRLAPSKPFT GCIRHFVIDG
1810 1820
HPVSFSKAAL VSGAVSINSC PAA
Length:1,823
Mass (Da):202,568
Last modified:January 7, 2015 - v1
Checksum:iA3A9F3230C391323
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590106 Genomic DNA. No translation available.
KF510935 Genomic DNA. No translation available.
Z99289 Genomic DNA. No translation available.
RefSeqiNP_001098676.2. NM_001105206.2.
XP_005267040.2. XM_005266983.3.
XP_005267041.2. XM_005266984.3.
UniGeneiHs.654572.

Genome annotation databases

EnsembliENST00000230538; ENSP00000230538; ENSG00000112769.
GeneIDi3910.
KEGGihsa:3910.
UCSCiuc003pvu.4. human.

Similar proteinsi

Entry informationi

Entry nameiA0A0A0MQS9_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MQS9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: December 20, 2017
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported