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Protein
Submitted name:

Estradiol 17-beta-dehydrogenase 1

Gene

HSD17B1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66NADPUniRule annotation1
Binding sitei143SubstrateUniRule annotation1
Active sitei156Proton acceptorUniRule annotation1
Binding sitei160NADPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 38NADPUniRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Estradiol 17-beta-dehydrogenase 1Imported
Gene namesi
Name:HSD17B1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108786.10.
HGNCiHGNC:5210. HSD17B1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108786.

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A0A0MQS7.
PRIDEiA0A0A0MQS7.

Expressioni

Gene expression databases

BgeeiENSG00000108786.
ExpressionAtlasiA0A0A0MQS7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MQS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00900000140775.
OMAiECGPVRT.
OrthoDBiEOG091G0E9O.

Family and domain databases

InterProiView protein in InterPro
IPR011348. 17beta_DH.
IPR036291. NAD(P)-bd_dom_sf.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0A0MQS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA
60 70 80 90 100
RALACPPGSL ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL
110 120 130 140 150
EALGEDAVAS VLDVNVVGTV RMLQAFLPDM KRRGSGRVLV TGSVGGLMGL
160 170 180 190 200
PFNDVYCASK FALEGLCESL AVLLLPFGVH SLSLIECGPV HTAFMEKVLG
210 220 230 240 250
SPEEVLDRTD IHTFHRFYQY LAHSKQVFRE AAQNPEEVAE VFLTALRAPK
260 270 280 290 300
PTLRYFTTER FLPLLRMRLD DPSGSNYVTA MHREVFGDVP AKAEAGAEAG
310 320
GGAGPGAEDE AGRGAVGDPE LGDPPAAPQ
Length:329
Mass (Da):35,037
Last modified:January 7, 2015 - v1
Checksum:iE8170FB5A0D14A3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067852 Genomic DNA. No translation available.
RefSeqiNP_001317148.1. NM_001330219.2.
UniGeneiHs.654385.
Hs.655222.

Genome annotation databases

EnsembliENST00000225929; ENSP00000225929; ENSG00000108786.
GeneIDi3292.
UCSCiuc060fjv.1. human.

Similar proteinsi

Entry informationi

Entry nameiA0A0A0MQS7_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MQS7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: January 31, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported