Sos2

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: InterPro
protein heterodimerization activity Source: InterPro
Rho guanyl-nucleotide exchange factor activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

positive regulation of small GTPase mediated signal transduction Source: Ensembl
regulation of Rho protein signal transduction Source: InterPro
small GTPase mediated signal transduction Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation

Molecular function

Guanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Son of sevenless homolog 2Imported
Gene namesⁱ	Name:Sos2Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:98355. Sos2.

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular Source: GOC

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	A0A0A0MQ87.
PRIDEⁱ	A0A0A0MQ87.

PTM databases

iPTMnetⁱ	A0A0A0MQ87.

iPTMnetⁱ

A0A0A0MQ87.

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	A0A0A0MQ87. baseline and differential.

ExpressionAtlasⁱ

A0A0A0MQ87. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: InterPro

Complete GO annotation...

Structureⁱ

3D structure databases

SMRⁱ	A0A0A0MQ87.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	199 – 388	DH (DBL-homology)InterPro annotationAdd BLAST	190
Domainⁱ	441 – 544	PHInterPro annotationAdd BLAST	104
Domainⁱ	595 – 739	N-terminal Ras-GEFInterPro annotationAdd BLAST	145
Domainⁱ	778 – 1017	Ras-GEFInterPro annotationAdd BLAST	240

Phylogenomic databases

eggNOGⁱ	KOG3417. Eukaryota. ENOG410XR96. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137850.
KEGG Orthology (KO) More...KOⁱ	K03099.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00155. RasGEF. 1 hit. cd06224. REM. 1 hit.
Gene3Dⁱ	1.10.840.10. 1 hit. 2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR009072. Histone-fold. IPR007125. Histone_H2A/H2B/H3. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR000651. Ras-like_Gua-exchang_fac_N. IPR019804. Ras_G-nucl-exch_fac_CS. IPR023578. Ras_GEF_dom. IPR001895. RASGEF_cat_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00125. Histone. 1 hit. PF00169. PH. 1 hit. PF00617. RasGEF. 1 hit. PF00618. RasGEF_N. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00233. PH. 1 hit. SM00147. RasGEF. 1 hit. SM00229. RasGEFN. 1 hit. SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF47113. SSF47113. 1 hit. SSF48065. SSF48065. 1 hit. SSF48366. SSF48366. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00720. RASGEF. 1 hit. PS50009. RASGEF_CAT. 1 hit. PS50212. RASGEF_NTER. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A0A0MQ87-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQQAPQPYEF FSEENSPKWR GLLVPALRKV QEQVHPTLSA NEESLYYIEE 
        60         70         80         90        100
LIFQLLNKLC MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR 
       110        120        130        140        150
NPLLLPVDKI HPSLKEVLGY KVDYHVSLYI VAVLEYISAD ILKLAGNYVF 
       160        170        180        190        200
NIRHYEISQQ DIKVSMCADK VLMDMFDQDD DIGLVSLCED EPCSSGELNY 
       210        220        230        240        250
YDLVRTEIAE ERQYLRELNM IIKVFREAFL LDRKLFKPSE IEKIFSNISD 
       260        270        280        290        300
IHELTVKLLG LIEDTVEMTD ESSPHPLAGS CFEDLAEEQA FDPYETLSQD 
       310        320        330        340        350
ILAPEFNDHF SKLMARPAVA LHFQSIADGF KEAVRYVLPR LMLVPVYHCW 
       360        370        380        390        400
HYFELLKLKA CSEEQEDKEC LNQAITALMN LQGSMDRIYK QHSPRRRPGD 
       410        420        430        440        450
PVCLFYNRQL RSKHLAIKKM NEIQKNIDGW EGKDIGQCCN EFIMEGPLTR 
       460        470        480        490        500
IGAKHERHIF LFDGLMISCK PNHGQTRLPG YSSAEYRLKE KFVMRKIQIC 
       510        520        530        540        550
DKEDACEYRH AFELVSKDEN SVIFAAKSAE EKNNWMAALI SLHYRSTLDR 
       560        570        580        590        600
MLDSVLLKEE NEQPLRLPSP DMYRFVVTDS EENIVFEDNL QSRSGIPIIK 
       610        620        630        640        650
GGTVVKLIER LTYHMYADPN FVRTFLTTYR SFCKPQELLN LLIERFEIPE 
       660        670        680        690        700
PEPTEADKLA LEKGEQPISA DLKRFRKEYV QPVQLRVLNV FRHWVEHHYY 
       710        720        730        740        750
DFERDLELLE RLESFISSVR GKAMKKWVES IAKIIKRKKQ AQANGISHNI 
       760        770        780        790        800
TFESSPPPVE WHISRTGQFE TFDLMTLHPI EIARQLTLLE SDLYRKVQPS 
       810        820        830        840        850
ELVGSVWTKE DKEINSPNLL KMIRHTTNLT LWFEKCIVEA ENFEERVAVL 
       860        870        880        890        900
SRIVEILQVF QDLNNFNGVL EIVSAVNSVS VYRLDHTFEA LQERKRRILD 
       910        920        930        940        950
DAVELSQDHF KKYLVKLKSI NPPCVPFFGI YLTNILKTEE GNSDFLKRKG 
       960        970        980        990       1000
KDLINFSKRR KVAEITGEIQ QYQNQPYCLR TEPEMRRFFE NLNPMGILSE 
      1010       1020       1030       1040       1050
KEFTDYLFNK SLEIEPRNCK QPPRFPRKST FSLKSPGIRP NAGRHGSTSG 
      1060       1070       1080       1090       1100
TLRGHPTPLE REPYKISFSR IAETELESTV SAPTSPNTPS TPPVSASSDH 
      1110       1120       1130       1140       1150
SVFLDVDLNS SCGSNTIFAP VLLPHSKTFF SSCGSLHKLS EEPLIPPPLP 
      1160       1170       1180       1190       1200
PRKKFDHDAL NSKGAVKSDD DPPAIPPRQP PPPKVKPRVP VLMGTFDGPV 
      1210       1220       1230       1240       1250
PSPPPPPPRD PLPDTPPPVP LRPPEHFINC PFNLQPPPLG HPHRDPDWLR 
      1260       1270       1280       1290       1300
DVSTCPNSPS TPPTTPSPRI PRSCHLLSSS HSSLAHLPAP PVPPRQNSSP 
      1310       1320       1330 
LLPKLPPKTY KRELSHPPLY RLPLLENAET PQ

Length:1,332

Mass (Da):152,998

Last modified:January 7, 2015 - v1

Checksum:ⁱ20152F41E400C1DB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC133949 Genomic DNA. No translation available. AC141560 Genomic DNA. No translation available. AC153658 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001129031.1. NM_001135559.1.
UniGeneⁱ	Mm.3770.

Genome annotation databases

Ensemblⁱ	ENSMUST00000035773; ENSMUSP00000044866; ENSMUSG00000034801.
GeneIDⁱ	20663.
KEGGⁱ	mmu:20663.
UCSC genome browser More...UCSCⁱ	uc007nso.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC133949 Genomic DNA. No translation available. AC141560 Genomic DNA. No translation available. AC153658 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001129031.1. NM_001135559.1.
UniGeneⁱ	Mm.3770.

3D structure databases

SMRⁱ	A0A0A0MQ87.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

iPTMnetⁱ	A0A0A0MQ87.

iPTMnetⁱ

A0A0A0MQ87.

Proteomic databases

PaxDbⁱ	A0A0A0MQ87.
PRIDEⁱ	A0A0A0MQ87.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000035773; ENSMUSP00000044866; ENSMUSG00000034801.
GeneIDⁱ	20663.
KEGGⁱ	mmu:20663.
UCSC genome browser More...UCSCⁱ	uc007nso.2. mouse.

Organism-specific databases

CTDⁱ	6655.
MGIⁱ	MGI:98355. Sos2.

Phylogenomic databases

eggNOGⁱ	KOG3417. Eukaryota. ENOG410XR96. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137850.
KEGG Orthology (KO) More...KOⁱ	K03099.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

ExpressionAtlasⁱ	A0A0A0MQ87. baseline and differential.

ExpressionAtlasⁱ

A0A0A0MQ87. baseline and differential.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00155. RasGEF. 1 hit. cd06224. REM. 1 hit.
Gene3Dⁱ	1.10.840.10. 1 hit. 2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR009072. Histone-fold. IPR007125. Histone_H2A/H2B/H3. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR000651. Ras-like_Gua-exchang_fac_N. IPR019804. Ras_G-nucl-exch_fac_CS. IPR023578. Ras_GEF_dom. IPR001895. RASGEF_cat_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00125. Histone. 1 hit. PF00169. PH. 1 hit. PF00617. RasGEF. 1 hit. PF00618. RasGEF_N. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00233. PH. 1 hit. SM00147. RasGEF. 1 hit. SM00229. RasGEFN. 1 hit. SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF47113. SSF47113. 1 hit. SSF48065. SSF48065. 1 hit. SSF48366. SSF48366. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00720. RASGEF. 1 hit. PS50009. RASGEF_CAT. 1 hit. PS50212. RASGEF_NTER. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A0A0MQ87_MOUSE
Accessionⁱ	A0A0A0MQ87Primary (citable) accession number: A0A0A0MQ87
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	January 7, 2015
	Last sequence update:	January 7, 2015
	Last modified:	July 5, 2017
	This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A0A0MQ87 (A0A0A0MQ87_MOUSE)

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Son of sevenless homolog 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ