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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Photorhabdus luminescens (Xenorhabdus luminescens)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotationSAAS annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotationSAAS annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB), Nicotinate phosphoribosyltransferase (pncB), Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseImported, LigaseUniRule annotationSAAS annotationImported, Transferase
Biological processPyridine nucleotide biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotationSAAS annotation (EC:6.3.4.21UniRule annotationSAAS annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
ORF Names:KS18_04580Imported
OrganismiPhotorhabdus luminescens (Xenorhabdus luminescens)Imported
Taxonomic identifieri29488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaePhotorhabdus
Proteomesi
  • UP000029997 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107RH7. Bacteria.
COG1488. LUCA.

Family and domain databases

HAMAPiMF_00570. NAPRTase. 1 hit.
InterProiView protein in InterPro
IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR036068. Nicotinate_pribotase_like_C.
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiView protein in Pfam
PF04095. NAPRTase. 1 hit.
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A0A0CU03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLDATPIIK SLLDTDAYKL HMQQAVYHRY SHMPVVAEFR CRGDEMLGEY
60 70 80 90 100
ATELRYQVNT MADLALTDAE FNYLSSLPFF KADYLDWLKT FRFNPQQVNI
110 120 130 140 150
SVTEGGQLAI RISGLWHEVI MWEVPLLALI SELVHRYHSP DNTVENAVNQ
160 170 180 190 200
LRKLIKLFYQ NAENEGIDLS NFKLMDFGTR RRFSHCVQHA IVSELQQHFP
210 220 230 240 250
YLIGTSNYQL AQQLGLPPVG TQAHEWFQAH QQISPDLANS QREALQSWLK
260 270 280 290 300
EYPNQLGIAL TDCITMDAFL RDFDAQFAKS YQGLRHDSGD PVQWGEKAIA
310 320 330 340 350
HYQKLDIDPM TKTLVFSDSL DFQKALALYR HFHNRINLIF GIGTQLTCNI
360 370 380 390 400
PGVKPLNIVI KLVECNGKPV AKLSDSPGKT ICEDNEFVNK LRAAFDIPQV

KQAC
Length:404
Mass (Da):46,197
Last modified:January 7, 2015 - v1
Checksum:i3B336BABCB393F88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQOC01000002 Genomic DNA. Translation: KGM29053.1.
RefSeqiWP_036807112.1. NZ_JQOC01000002.1.

Genome annotation databases

EnsemblBacteriaiKGM29053; KGM29053; KS18_04580.

Similar proteinsi

Entry informationi

Entry nameiA0A0A0CU03_PHOLU
AccessioniPrimary (citable) accession number: A0A0A0CU03
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: October 25, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported