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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Helicobacter sp. MIT 11-5569
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotationSAAS annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotationSAAS annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotation
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotationSAAS annotation (EC:6.4.1.2UniRule annotationSAAS annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
ORF Names:LS70_01650Imported, LS70_09590Imported
OrganismiHelicobacter sp. MIT 11-5569Imported
Taxonomic identifieri1548151 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000029923 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 286CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the AccA family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_00823. AcetylCoA_CT_alpha. 1 hit.
InterProiView protein in InterPro
IPR001095. Acetyl_CoA_COase_a_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011763. COA_CT_C.
PANTHERiPTHR42853. PTHR42853. 1 hit.
PfamiView protein in Pfam
PF03255. ACCA. 1 hit.
PRINTSiPR01069. ACCCTRFRASEA.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00513. accA. 1 hit.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A099TVM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYLDFEVK IKNIQENIAT AQLKNDAHAI AILQKDLDKE VTKVYSNLSD
60 70 80 90 100
YQKLQLARHP DRPYAMDYIT LLLEEPLEIH GDRHFSDDHA VVCFLGKIDN
110 120 130 140 150
QKVMVIGEEK GRGTKNKLYR NFGMPNPEGY RKALRTAKMA EKFGIPLLMF
160 170 180 190 200
VDTPGAYPGI GAEERGQSEA IAKNLQEFSA LKIPTISIVI GEGGSGGALA
210 220 230 240 250
IGVADRLAMM QYSVFSVISP EGCAAILWND PAKIENATQA LKITPEDLKA
260 270 280 290 300
ANLIDAIIQE PGIGAHRDKE GAAEMIKTYF LESLEAIRKD PDFLNKRFSK

LMNYGSFQA
Length:309
Mass (Da):34,222
Last modified:January 7, 2015 - v1
Checksum:i17CDAF3976D7E211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JRPB01000020 Genomic DNA. Translation: KGL10345.1.
JRPB01000001 Genomic DNA. Translation: KGL11480.1.
RefSeqiWP_034287361.1. NZ_JRPB01000020.1.

Genome annotation databases

EnsemblBacteriaiKGL10345; KGL10345; LS70_09590.
KGL11480; KGL11480; LS70_01650.

Similar proteinsi

Entry informationi

Entry nameiA0A099TVM3_9HELI
AccessioniPrimary (citable) accession number: A0A099TVM3
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: November 22, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported