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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Mycobacterium rufum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (EU78_12940)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei161SubstrateUniRule annotation1
Binding sitei211ATPUniRule annotation1
Binding sitei299ATP; via carbonyl oxygenUniRule annotation1
Binding sitei330ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi359 – 362ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processGlycolysisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotationSAAS annotation (EC:2.7.2.3UniRule annotationSAAS annotation)
Gene namesi
Name:pgkUniRule annotationImported
ORF Names:EU78_12305Imported
OrganismiMycobacterium rufumImported
Taxonomic identifieri318424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000029688 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Monomer.UniRule annotationSAAS annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingUniRule annotation3
Regioni62 – 65Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 3 hits.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiView protein in InterPro
IPR001576. Phosphoglycerate_kinase.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
IPR036043. Phosphoglycerate_kinase_sf.
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiView protein in Pfam
PF00162. PGK. 1 hit.
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiView protein in PROSITE
PS00111. PGLYCERATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A099CI37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKSLEDLL AEGVSGRGVL VRSDLNVPLD GDRITDPGRI IASVPTLKAL
60 70 80 90 100
SDAGAKVVVT AHLGRPKGEP DPKFSLKPVA AALADKLGRH VQLAGDVVGS
110 120 130 140 150
DALARAEGLT DGDILLLENI RFDARETSKD DAERRALATA LVELVGDDGA
160 170 180 190 200
FVSDGFGVVH RKQASVYDVA TLLPHYAGTL VDTEVKVLAQ LTESTERPYA
210 220 230 240 250
VVLGGSKVSD KLAVIENLAT KADSLIIGGG MCFTFLAAQG LSVGSSLLEE
260 270 280 290 300
SMIETCRKLL DDYGDVLHLP VDIVVAEKFA ADSPAETVAA DKIPDDRMGL
310 320 330 340 350
DIGPESVKRF TALLSNARTI FWNGPMGVFE FPAFSAGTKG VAEAIIAATG
360 370 380 390 400
KGAFSVVGGG DSAAAVRQLG LPDDGFSHIS TGGGASLEYL EGKELPGIRV

LSS
Length:403
Mass (Da):41,891
Last modified:January 7, 2015 - v1
Checksum:i4C234D017BE7C699
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JROA01000001 Genomic DNA. Translation: KGI68087.1.

Genome annotation databases

EnsemblBacteriaiKGI68087; KGI68087; EU78_12305.

Similar proteinsi

Entry informationi

Entry nameiA0A099CI37_9MYCO
AccessioniPrimary (citable) accession number: A0A099CI37
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: March 28, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported