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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Helicobacter sp. MIT 03-1614
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotationSAAS annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotationSAAS annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotation
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotationSAAS annotation (EC:6.4.1.2UniRule annotationSAAS annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
ORF Names:LS66_08235Imported
OrganismiHelicobacter sp. MIT 03-1614Imported
Taxonomic identifieri1548147 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000029698 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA0A099BQU7.
SMRiA0A099BQU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 286CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST251

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili4 – 24Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the AccA family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

HAMAPiMF_00823. AcetylCoA_CT_alpha. 1 hit.
InterProiView protein in InterPro
IPR001095. Acetyl_CoA_COase_a_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011763. COA_CT_C.
PANTHERiPTHR42853. PTHR42853. 1 hit.
PfamiView protein in Pfam
PF03255. ACCA. 1 hit.
PRINTSiPR01069. ACCCTRFRASEA.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00513. accA. 1 hit.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A099BQU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYLDFEQK IKNLQDDIES AIISGDNDAI SILEKELEKE VSSVYSNISD
60 70 80 90 100
YQKLQLARHP DRPYAMDYIE SILKNPYEIN GDRHFKDDKA IVCFLGKIGE
110 120 130 140 150
QTTMIIGEEK GRGTKNKLAR NFGMPSPEGY RKALRAAKLA EKFHIPILML
160 170 180 190 200
VDTQGAYPGL GAEERGQSEA IARNLQEFAK LKTPTIAVVI GEGGSGGALA
210 220 230 240 250
IAVADKLAMM QYSIFSVISP EGCAAILWND PSKIESATKA LKITPIELKK
260 270 280 290 300
CGLIDDVINE PLIGAHRDKE SAAKAIESYF LKAFEEISQD DNYLNKRYQK

LMNYGAFS
Length:308
Mass (Da):34,137
Last modified:January 7, 2015 - v1
Checksum:i42A608D4F205B3CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JRMS01000049 Genomic DNA. Translation: KGI57908.1.
RefSeqiWP_011115568.1. NZ_JRMS01000049.1.

Genome annotation databases

EnsemblBacteriaiKGI57908; KGI57908; LS66_08235.

Similar proteinsi

Entry informationi

Entry nameiA0A099BQU7_9HELI
AccessioniPrimary (citable) accession number: A0A099BQU7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: December 20, 2017
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported