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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Geobacillus thermoleovorans B23
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotationSAAS annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationSAAS annotation (EC:1.4.4.2UniRule annotationSAAS annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
ORF Names:B23_1416Imported
OrganismiGeobacillus thermoleovorans B23Imported
Taxonomic identifieri1406857 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillusGeobacillus thermoleovorans group
Proteomesi
  • UP000029900 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00613. GDC-P. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00712. GcvPA. 1 hit.
InterProiView protein in InterPro
IPR023010. GcvPA.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015422. PyrdxlP-dep_Trfase_dom1.
IPR015421. PyrdxlP-dep_Trfase_major.
PfamiView protein in Pfam
PF02347. GDC-P. 1 hit.
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A098L339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPKRQGKG KNAVLHRYLP MTEEDKQEML KTIGVASIDD LFADIPEQVR
60 70 80 90 100
FRGELKVKPA KSEPELWKEL AALAEKNASV KQYVSFLGAG VYDHYIPAVV
110 120 130 140 150
DHVLSRSEFY TAYTPYQPEI SQGELQAIFE FQTMVCELTG MDVANSSMYD
160 170 180 190 200
GGTALAEAVL LSAAHTKRKK VLISTAVHPQ YREVVRTYAK GQKLEVKEIP
210 220 230 240 250
YDGGITDLKA LEAEMGDDVA CVVVQYPNFF GQIEPLKAIA PLAHEKKSLF
260 270 280 290 300
VVASNPLALG VLTPPGAFGA DIVVGDMQPF GIPTQFGGPH CGYFAVKAPL
310 320 330 340 350
MRKIPGRLVG QTTDEDGRRG FVLTLQAREQ HIRRDKATSN ICSNQALNAL
360 370 380 390 400
AASVALSALG KRGVKEMAAM NIQKAHYAKV ELEKRGLSSP FAGPFFNEFV
410 420 430 440 450
IRLGRPVSDV NDRLLEKGII GGYDLGADYP ELAGHMLVAV TELRTKEEID
460
RFVNELGDGH A
Length:461
Mass (Da):50,478
Last modified:January 7, 2015 - v1
Checksum:i45FD795B9C49168F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BATY01000091 Genomic DNA. Translation: GAJ58210.1.

Genome annotation databases

EnsemblBacteriaiGAJ58210; GAJ58210; B23_1416.

Similar proteinsi

Entry informationi

Entry nameiA0A098L339_GEOTH
AccessioniPrimary (citable) accession number: A0A098L339
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: February 28, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported