gcvPA

Functionⁱ

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO₂ is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotationSAAS annotation

Catalytic activityⁱ

Glycine + [glycine-cleavage complex H protein]-N₆-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N₆-dihydrolipoyl-L-lysine + CO₂.UniRule annotationSAAS annotation

GO - Molecular functionⁱ

glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glycine decarboxylation via glycine cleavage system Source: UniProtKB-UniRule
nucleoside metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	OxidoreductaseUniRule annotationSAAS annotation

Molecular function

OxidoreductaseUniRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationSAAS annotation (EC:1.4.4.2UniRule annotationSAAS annotation) Alternative name(s): Glycine cleavage system P-protein subunit 1UniRule annotation Glycine decarboxylase subunit 1UniRule annotation Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesⁱ	Name:gcvPAUniRule annotation ORF Names:B23_1416Imported
Organismⁱ	Geobacillus thermoleovorans B23Imported
Taxonomic identifierⁱ	1406857 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Bacillales › Bacillaceae › Geobacillus › Geobacillus thermoleovorans group › Geobacillus thermoleovorans
Proteomesⁱ	UP000029900 Componentⁱ: Unassembled WGS sequence

Interactionⁱ

Subunit structureⁱ

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotationSAAS annotation

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00613. GDC-P. 1 hit.
Gene3Dⁱ	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAPⁱ	MF_00712. GcvPA. 1 hit.
InterProⁱ	View protein in InterPro IPR023010. GcvPA. IPR020581. GDC_P. IPR015424. PyrdxlP-dep_Trfase. IPR015422. PyrdxlP-dep_Trfase_dom1. IPR015421. PyrdxlP-dep_Trfase_major.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02347. GDC-P. 1 hit.
PIRSFⁱ	PIRSF006815. GcvPA. 1 hit.
SUPFAMⁱ	SSF53383. SSF53383. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A098L339-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTIPKRQGKG KNAVLHRYLP MTEEDKQEML KTIGVASIDD LFADIPEQVR 
        60         70         80         90        100
FRGELKVKPA KSEPELWKEL AALAEKNASV KQYVSFLGAG VYDHYIPAVV 
       110        120        130        140        150
DHVLSRSEFY TAYTPYQPEI SQGELQAIFE FQTMVCELTG MDVANSSMYD 
       160        170        180        190        200
GGTALAEAVL LSAAHTKRKK VLISTAVHPQ YREVVRTYAK GQKLEVKEIP 
       210        220        230        240        250
YDGGITDLKA LEAEMGDDVA CVVVQYPNFF GQIEPLKAIA PLAHEKKSLF 
       260        270        280        290        300
VVASNPLALG VLTPPGAFGA DIVVGDMQPF GIPTQFGGPH CGYFAVKAPL 
       310        320        330        340        350
MRKIPGRLVG QTTDEDGRRG FVLTLQAREQ HIRRDKATSN ICSNQALNAL 
       360        370        380        390        400
AASVALSALG KRGVKEMAAM NIQKAHYAKV ELEKRGLSSP FAGPFFNEFV 
       410        420        430        440        450
IRLGRPVSDV NDRLLEKGII GGYDLGADYP ELAGHMLVAV TELRTKEEID 
       460 
RFVNELGDGH A

Length:461

Mass (Da):50,478

Last modified:January 7, 2015 - v1

Checksum:ⁱ45FD795B9C49168F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BATY01000091 Genomic DNA. Translation: GAJ58210.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

BATY01000091 Genomic DNA. Translation: GAJ58210.1.

Genome annotation databases

EnsemblBacteriaⁱ	GAJ58210; GAJ58210; B23_1416.

EnsemblBacteriaⁱ

GAJ58210; GAJ58210; B23_1416.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A098L339	U2WQD7 G8N250 L8A124	Geobacillus kaustophilus GBlys Geobacillus thermoleovorans CCB_US3_UF5 Geobacillus sp. GHH01	461	UniRef100_U2WQD7	Cluster: Probable glycine dehydrogenase (decarboxylating) subunit 1	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A098L339	A4IQV4 A0A0Q0UT82 A0A1W6VU77 U2WQD7 G8N250 L8A124 A0A1Q5T3B0 A0A150N021 S7U7T0 Q5KX77 +39	Geobacillus thermodenitrificans (strain NG80-2) Geobacillus sp. PA-3 Geobacillus thermodenitrificans Geobacillus kaustophilus GBlys Geobacillus thermoleovorans CCB_US3_UF5 Geobacillus sp. GHH01 Geobacillus sp. 1017 Geobacillus sp. B4113_201601 Geobacillus sp. WSUCF1 Geobacillus kaustophilus (strain HTA426) And more	448	UniRef90_A4IQV4	Cluster: Probable glycine dehydrogenase (decarboxylating) subunit 1	50

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A098L339	P54376 A0A1B2AXL0 G4ETW8 A0A164X7M4 A0A125UJW7 L8ANI1 A0A2C6FA56 UPI00084025D6 UPI000C22DBB5 UPI0004671B88 +2330	Bacillus subtilis (strain 168) Bacillus subtilis subsp. subtilis Bacillus subtilis subsp. subtilis str. SC-8 Bacillus subtilis Bacillus sp. LM 4-2 Bacillus subtilis BEST7613 Bacillus halotolerans Bacillus Bacillus sp. SN1 Bacillus tequilensis And more	448	UniRef50_P54376	Cluster: Probable glycine dehydrogenase (decarboxylating) subunit 1	2,341

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BATY01000091 Genomic DNA. Translation: GAJ58210.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

BATY01000091 Genomic DNA. Translation: GAJ58210.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	GAJ58210; GAJ58210; B23_1416.

EnsemblBacteriaⁱ

GAJ58210; GAJ58210; B23_1416.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00613. GDC-P. 1 hit.
Gene3Dⁱ	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAPⁱ	MF_00712. GcvPA. 1 hit.
InterProⁱ	View protein in InterPro IPR023010. GcvPA. IPR020581. GDC_P. IPR015424. PyrdxlP-dep_Trfase. IPR015422. PyrdxlP-dep_Trfase_dom1. IPR015421. PyrdxlP-dep_Trfase_major.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02347. GDC-P. 1 hit.
PIRSFⁱ	PIRSF006815. GcvPA. 1 hit.
SUPFAMⁱ	SSF53383. SSF53383. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A098L339_GEOTH
Accessionⁱ	A0A098L339Primary (citable) accession number: A0A098L339
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	January 7, 2015
	Last sequence update:	January 7, 2015
	Last modified:	February 28, 2018
	This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB - A0A098L339 (A0A098L339_GEOTH)

Your basket is currently empty. ⁱ

Probable glycine dehydrogenase (decarboxylating) subunit 1

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Interactionⁱ

Subunit structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Caution

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A098L339 (A0A098L339_GEOTH)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Probable glycine dehydrogenase (decarboxylating) subunit 1

gcvPA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ