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Protein

Gap junction protein

Gene

GJA8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.UniRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction proteinUniRule annotation
Gene namesi
Name:GJA8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei58 – 80HelicalSequence analysisAdd BLAST23
Transmembranei131 – 152HelicalSequence analysisAdd BLAST22
Transmembranei184 – 209HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Gap junctionUniRule annotationSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500193114722 – 327Gap junction proteinSequence analysisAdd BLAST306

Proteomic databases

PaxDbiA0A097IW54.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 56CNXInterPro annotationAdd BLAST34
Domaini141 – 207Connexin_CCCInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the connexin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IF3Z. Eukaryota.
ENOG410ZC96. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR002266. Connexin50.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF19. PTHR11984:SF19. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PF03509. Connexin50. 1 hit.
PRINTSiPR00206. CONNEXIN.
PR01137. CONNEXINA8.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

A0A097IW54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IGRVWLTVLF IFRILILGTA AEFVWGDEQS DFVCNTQQPG CENVCYDEAF
60 70 80 90 100
PISHIRLWVL QIIFVSTPSL MYVGHAVHYV RMEEKRKSRE AEELGQQAGT
110 120 130 140 150
NGGPDQGSVK KSSGSKGTKK FRLEGTLLRT YICHIIFKTL FEVGFIVGHY
160 170 180 190 200
FLYGFRILPL YRCSRWPCPN VVDCFVSRPT EKTIFILFML SVASVSLFLN
210 220 230 240 250
VMELGHLGLK GIRSALKRPV EQPLGEIPEK SLHSIAVSSI QKAKGYQLLE
260 270 280 290 300
EEKIVSHYFP LTEVGMVETS PLPAKPFNQF EEKISTGPLG DLSRGYQETL
310 320
PSYAQVGAQE VEGEGPPAEE GAEPEVG
Length:327
Mass (Da):36,523
Last modified:January 7, 2015 - v1
Checksum:i0C84A4850057325A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei327Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM190136 Genomic DNA. Translation: AIT70957.1.
UniGeneiHs.632441.

Similar proteinsi

Entry informationi

Entry nameiA0A097IW54_HUMAN
AccessioniPrimary (citable) accession number: A0A097IW54
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: October 25, 2017
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.