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Protein

NADH-ubiquinone oxidoreductase chain 6

Gene

ND6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandNADSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 6UniRule annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:ND6Imported
Encoded oniMitochondrionImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 46HelicalSequence analysisAdd BLAST22
Transmembranei53 – 75HelicalSequence analysisAdd BLAST23
Transmembranei81 – 104HelicalSequence analysisAdd BLAST24
Transmembranei111 – 128HelicalSequence analysisAdd BLAST18
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_501328885016 – 174NADH-ubiquinone oxidoreductase chain 6Sequence analysisAdd BLAST159

Proteomic databases

PeptideAtlasiA0A096W049.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 6 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IYM9. Eukaryota.
ENOG410YP23. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR001457. NADH_UbQ/plastoQ_OxRdtase_su6.
PfamiView protein in Pfam
PF00499. Oxidored_q3. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A096W049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMYALFLLSV GLVMGFVGFS SKPSPIYGGL VLIVSGVVGC VIILNFGGGY
60 70 80 90 100
MGLMVFLIYL GGMMVVFGYT TAMAIEEYPE AWGSGVEVLV SVLVGLAMEV
110 120 130 140 150
GLVLWVKEYD GVVVVVNFNS VGSWMIYEGE GSVLIREDPI GAGALYDYGR
160 170
WLVVVTGWTL FVGVYIVIEI ARGN
Length:174
Mass (Da):18,664
Last modified:January 7, 2015 - v1
Checksum:iE5189CE7BFFC600D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC252554 Genomic DNA. Translation: AGX92590.1.

Similar proteinsi

Entry informationi

Entry nameiA0A096W049_HUMAN
AccessioniPrimary (citable) accession number: A0A096W049
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: February 28, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.