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Protein

Purine nucleoside phosphorylase

Gene

PNP

Organism
Papio anubis (Olive baboon)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33PhosphateUniRule annotation1
Binding sitei64PhosphateUniRule annotation1
Binding sitei116Phosphate; via amide nitrogenUniRule annotation1
Binding sitei201Purine nucleosideUniRule annotation1
Binding sitei220PhosphateUniRule annotation1
Binding sitei243Purine nucleosideUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00606.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
Gene namesi
Name:PNPImported
OrganismiPapio anubis (Olive baboon)Imported
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
Proteomesi
  • UP000028761 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

ExpressionAtlasiA0A096NNL6. baseline.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 275PNP_UDP_1InterPro annotationAdd BLAST249

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 86Phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074740.
OMAiVLISDHI.
OrthoDBiEOG091G0GEE.

Family and domain databases

InterProiView protein in InterPro
IPR000845. Nucleoside_phosphorylase_d.
IPR035994. Nucleoside_phosphorylase_sf.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
IPR018099. Purine_phosphorylase-2_CS.
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiView protein in Pfam
PF01048. PNP_UDP_1. 1 hit.
PIRSFiPIRSF000477. PurNPase. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.
PROSITEiView protein in PROSITE
PS01240. PNP_MTAP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A096NNL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENGYTYEDY KNTAEWLLSH TKHRPQVAII CGSGLGGLTD KLTEAQIFDY
60 70 80 90 100
SEIPNFPQST VPGHVGRLVF GFLNGKACVI MQGRFHMYEG YSLWKVTFPV
110 120 130 140 150
RVFHLLGVDT LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FSGQNPLRGP
160 170 180 190 200
NDERFGVRFP AMSDAYDRTM RQRALSMWKQ MGEQRELQEG TYVMLAGPSF
210 220 230 240 250
ETVAESRLLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVIMDYE
260 270 280
SLEKANHEEV LAAGKQATQK LEQLVSILMA SIPPPDKAS
Length:289
Mass (Da):32,099
Last modified:November 26, 2014 - v1
Checksum:i7BCD2DA4BB3936A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHZZ01069232 Genomic DNA. No translation available.
RefSeqiXP_003901540.1. XM_003901491.3.

Genome annotation databases

EnsembliENSPANT00000029094; ENSPANP00000014576; ENSPANG00000020785.
GeneIDi101002247.

Similar proteinsi

Entry informationi

Entry nameiA0A096NNL6_PAPAN
AccessioniPrimary (citable) accession number: A0A096NNL6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: October 25, 2017
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported