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Protein

Cytochrome P450

Gene

CYP1A2

Organism
Papio anubis (Olive baboon)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases.UniRule annotation

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.UniRule annotation

Cofactori

hemeUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
LigandHemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450UniRule annotation (EC:1.14.14.1UniRule annotation)
Gene namesi
Name:CYP1A2Imported
OrganismiPapio anubis (Olive baboon)Imported
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
Proteomesi
  • UP000028761 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 48HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, MicrosomeUniRule annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00900000140831.
OMAiYTNGLNM.
OrthoDBiEOG091G0BT8.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A096NMR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LQTSHYNSAN LKHLPLQLVQ MALSQSVPFS ATELLLASAI FCLVFWVLRG
60 70 80 90 100
SRPQVPKGLK SPPEPWGWPL LGHVLTLGKN PHLALSRMSQ LYGDVLQIRI
110 120 130 140 150
GSTPVLVLSG LDTIRQALVR QGDDFKGRPD LYSFTFITDG QSMSFSPDSG
160 170 180 190 200
PVWAARRRLA QNALNTFSIA SDPASSSSCY LEEHVSKEAE ALSSRLQELM
210 220 230 240 250
AGPGHFDPYN QVVVSVANVI GAMCFGQHYP ESSDEMLSLV KNSHEFVESA
260 270 280 290 300
SSGNPVDFFP ILRYLPNPAL QRFKAFNQRF RQFLQKTVQE HYQDFDKNSV
310 320 330 340 350
QDITGALFKH SKKGPRASGN LIPQEKIVNL VNDIFGAGFD TIATAISWSL
360 370 380 390 400
MYLVTKPEIQ RKIQKELDAV IGRGRRPRLS DRLQLPYLEA FILETFRHSS
410 420 430 440 450
FVPFTIPHST TRDTTLNGFY IPRECCVFIN QWQVNHDPQL WGDPSEFRPE
460 470 480 490 500
RFLTAEGTTI NKPLSEKIML FGLGKRRCIG EVLGKWEVFL FLAILLQQLE
510 520 530
FSVPPGVKVD LTPIYGLTMK HARCEHFQAR LRFSIK
Length:536
Mass (Da):60,407
Last modified:November 26, 2014 - v1
Checksum:iD03952E1D2F77127
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHZZ01198632 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSPANT00000004824; ENSPANP00000014274; ENSPANG00000015999.

Similar proteinsi

Entry informationi

Entry nameiA0A096NMR5_PAPAN
AccessioniPrimary (citable) accession number: A0A096NMR5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: October 25, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported