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Protein

Hemopexin

Gene

HPX

Organism
Papio anubis (Olive baboon)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransportUniRule annotation
LigandHemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HemopexinUniRule annotation
Gene namesi
Name:HPXImported
OrganismiPapio anubis (Olive baboon)Imported
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
Proteomesi
  • UP000028761 Componenti: Chromosome 14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500192216824 – 462HemopexinSequence analysisAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 231UniRule annotation
Disulfide bondi149 ↔ 154UniRule annotation
Disulfide bondi188 ↔ 200UniRule annotation
Disulfide bondi366 ↔ 408UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 93HemopexinPROSITE-ProRule annotationAdd BLAST41
Repeati94 – 139HemopexinPROSITE-ProRule annotationAdd BLAST46
Repeati140 – 184HemopexinPROSITE-ProRule annotationAdd BLAST45
Repeati185 – 231HemopexinPROSITE-ProRule annotationAdd BLAST47
Repeati259 – 304HemopexinPROSITE-ProRule annotationAdd BLAST46
Repeati305 – 352HemopexinPROSITE-ProRule annotationAdd BLAST48
Repeati357 – 396HemopexinPROSITE-ProRule annotationAdd BLAST40
Repeati400 – 450HemopexinPROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Belongs to the hemopexin family.UniRule annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000009178.
OMAiAVECHRG.
OrthoDBiEOG091G052J.

Family and domain databases

CDDicd00094. HX. 2 hits.
Gene3Di2.110.10.10. 2 hits.
InterProiView protein in InterPro
IPR016358. Hemopexin.
IPR000585. Hemopexin-like_dom.
IPR036375. Hemopexin-like_dom_sf.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
PfamiView protein in Pfam
PF00045. Hemopexin. 4 hits.
PIRSFiPIRSF002551. Hemopexin_chordata. 1 hit.
SMARTiView protein in SMART
SM00120. HX. 5 hits.
SUPFAMiSSF50923. SSF50923. 2 hits.
PROSITEiView protein in PROSITE
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 8 hits.

Sequencei

Sequence statusi: Complete.

A0A096N345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARALGAPVA LGLWSLCWSL AIANPLPPTS AHGNVAEGET KPDPDVTERC
60 70 80 90 100
SDGWSFDATT LDDNGTMLFF KGEFVWKSHK WARELISETW KNFTSPVDAA
110 120 130 140 150
FRHGHKSVFL IKGDKVWVYP PEKKEKGYPK LLQDKFPGIP SPLDAAVECH
160 170 180 190 200
RGECQAEGIL FFQGDHKWFW DLATGTMKKR YWSAVGNCSS ALRWLGRYYC
210 220 230 240 250
FQGNQFLRFN PVTGEVPPRY PLDVRDYFMP CPGRGHGHRN GTGHGNGTHH
260 270 280 290 300
SPEYMRCSPH LVLSALMSDN HGATYAFSGT HYWRLDTSRD GWHSWPIAHQ
310 320 330 340 350
WPQGPSTVDA AFSWEEKLYL VQGTQVYVFL TKGGYTLVSG YPKRLEKEVG
360 370 380 390 400
SPHGIILDSV DAAFVCPGSS RLHIMAGRRL WWLDLKSGAQ ATWTELPWPH
410 420 430 440 450
EKVDGALCVE KSLGPNSCSA NGPGLYLIHG PNLYCYSDVE KLNAAKSPPQ
460
PQKVTSLLGC TH
Length:462
Mass (Da):51,562
Last modified:November 26, 2014 - v1
Checksum:i22EC36540DC048E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHZZ02007027 Genomic DNA. No translation available.
RefSeqiXP_003910344.1. XM_003910295.2.

Genome annotation databases

EnsembliENSPANT00000012416; ENSPANP00000006751; ENSPANG00000014360.
GeneIDi101011145.

Similar proteinsi

Entry informationi

Entry nameiA0A096N345_PAPAN
AccessioniPrimary (citable) accession number: A0A096N345
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: March 28, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported