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Protein
Submitted name:

Integrin subunit alpha 4

Gene

ITGA4

Organism
Papio anubis (Olive baboon)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin subunit alpha 4Imported
Gene namesi
Name:ITGA4Imported
OrganismiPapio anubis (Olive baboon)Imported
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
Proteomesi
  • UP000028761 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei976 – 1001HelicalUniRule annotationAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33UniRule annotationAdd BLAST33
ChainiPRO_500142286134 – 1033UniRule annotationAdd BLAST1000

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 100FG-GAPPROSITE-ProRule annotationAdd BLAST66
Repeati110 – 177FG-GAPPROSITE-ProRule annotationAdd BLAST68
Repeati185 – 237FG-GAPPROSITE-ProRule annotationAdd BLAST53
Repeati238 – 291FG-GAPPROSITE-ProRule annotationAdd BLAST54
Repeati292 – 351FG-GAPPROSITE-ProRule annotationAdd BLAST60
Repeati355 – 412FG-GAPPROSITE-ProRule annotationAdd BLAST58
Repeati416 – 478FG-GAPPROSITE-ProRule annotationAdd BLAST63
Domaini463 – 870Integrin_alpha2InterPro annotationAdd BLAST408

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118782.
OMAiNRRDSWS.
OrthoDBiEOG091G011V.

Family and domain databases

InterProiView protein in InterPro
IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom_sf.
PfamiView protein in Pfam
PF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PRINTSiPR01185. INTEGRINA.
SMARTiView protein in SMART
SM00191. Int_alpha. 5 hits.
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiView protein in PROSITE
PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A096N244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWEARREPG PRRAALRETV MLLLCLGVPT GRPYNVDTES ALLYQGPPNT
60 70 80 90 100
LFGYSVVLHS HGANRWLVVG APTANWLANA SVINPGAIYR CRIGKNPGRT
110 120 130 140 150
CEQLQLGSPN GEPCGKTCLE ERDNQWLGVT LSRQPGENGS IVTCGHRWKN
160 170 180 190 200
IFYIKNENKL PTGGCYGMPP DLRTELSKRI APCYQDYVKK FGENFASCQA
210 220 230 240 250
GISSFYTKDL IVMGAPGSSY WTGSLFVYNI TTNKYKAFLD KQNQVKFGSY
260 270 280 290 300
LGYSVGAGHF RSQHTTEVVG GAPQHEQIGK AYIFSIDEKE LNILHEMKGK
310 320 330 340 350
KLGSYFGASV CAVDLNADGF SDLLVGAPMQ STIREEGRVF VYINSGSGAV
360 370 380 390 400
MNEMETNLVG SDKYAARFGE CIVNLGDIDN DGFEDVAIGA PQEDDLQGAI
410 420 430 440 450
YIYNGRADGV SSAFSQRIEG LQISKSLSMF GQSISGQIDA DNNGYVDVAV
460 470 480 490 500
GAFRSDSAVL LRTRPVVIVE ASLSHPESVN RTKFDCVENG WPSVCMDLTL
510 520 530 540 550
CFSYKGKEVP GYIVLFYNMS LDVNRKTESP PRFYFSSNGT SDVITGSIQV
560 570 580 590 600
SSGVANCRTH QAFMRKDVRD ILTPIQIEAA YHLGPHVISK RSTEEFPPLQ
610 620 630 640 650
PILQQKKEKD IIKKTMGITG KCQDRTLSAE VAKITVQLGS IKPHENKTYL
660 670 680 690 700
AVGSMKTLMF NVSLFNAGDD AYETTLHVKL PMGLYFIKIL ELEEKQINCE
710 720 730 740 750
VTDNSGMVQL DCSIGYIYVD HLSRIEISFL LDVSSLSRAE EDLNITVHAT
760 770 780 790 800
CENEGEMDNL KHSRVTVAIP LKYEVKLTVH GFVNPTSFVY GSNDENEPEM
810 820 830 840 850
CMVEKMNLTF HVINTGNSMA PNVSVEIMVP NSFSPQTDKL FNILDVQTTT
860 870 880 890 900
GECHFENYQR VCALEQQKSA MHILKGMFQF LSKTDKRLLY CIKADPHCLN
910 920 930 940 950
FLCNFGKMES GKEASVHIQL EGRPSILEMD ETSALKFEIR ATSFPEPNSR
960 970 980 990 1000
VIELNKDENV AHVLLEGLHH QRPRRYFTIV IISSSLLLGL IVLLLISYVM
1010 1020 1030
WKAGFFKRQY KSILQEENRR DSWSYINSKS NDD
Length:1,033
Mass (Da):115,034
Last modified:November 26, 2014 - v1
Checksum:iE7468F060D62BE06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHZZ01075066 Genomic DNA. No translation available.
AHZZ01075067 Genomic DNA. No translation available.
AHZZ01075068 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSPANT00000016332; ENSPANP00000006386; ENSPANG00000007919.

Similar proteinsi

Entry informationi

Entry nameiA0A096N244_PAPAN
AccessioniPrimary (citable) accession number: A0A096N244
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: November 22, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported