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Protein

GMP reductase

Gene

GMPR

Organism
Cuculus canorus (common cuckoo)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78NADPUniRule annotation1
Metal bindingi181Potassium; via carbonyl oxygenUniRule annotation1
Metal bindingi183Potassium; via carbonyl oxygenUniRule annotation1
Active sitei186Thioimidate intermediateUniRule annotation1
Metal bindingi186Potassium; via carbonyl oxygenUniRule annotation1
Active sitei188Proton donor/acceptorUniRule annotation1
Metal bindingi189PotassiumUniRule annotation1
Binding sitei269NADP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 27NADP; shared with neighboring subunitUniRule annotation2
Nucleotide bindingi129 – 131NADPUniRule annotation3
Nucleotide bindingi180 – 181NADPUniRule annotation2
Nucleotide bindingi285 – 286NADPUniRule annotation2
Nucleotide bindingi314 – 317NADP; shared with neighboring subunitUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processPurine metabolismUniRule annotation
LigandMetal-bindingUniRule annotation, NADPUniRule annotation, PotassiumUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
GMP reductaseUniRule annotation (EC:1.7.1.7UniRule annotation)
Short name:
GMPRUniRule annotation
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductaseUniRule annotation
Short name:
Guanosine monophosphate reductaseUniRule annotation
Gene namesi
Name:GMPRUniRule annotation
ORF Names:N303_07704Imported
OrganismiCuculus canorus (common cuckoo)Imported
Taxonomic identifieri55661 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeCuculiformesCuculidaeCuculus
Proteomesi
  • UP000053760 Componenti: Unassembled WGS sequence

Subcellular locationi

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 339IMPDHInterPro annotationAdd BLAST330

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 221GMP bindingUniRule annotation3
Regioni242 – 243GMP bindingUniRule annotation2
Regioni268 – 270GMP bindingUniRule annotation3
Regioni286 – 290GMP bindingUniRule annotation5

Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.UniRule annotation

Family and domain databases

CDDicd00381. IMPDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00596. GMP_reduct_type1. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR005993. GMPR.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
PfamiView protein in Pfam
PF00478. IMPDH. 1 hit.
PIRSFiPIRSF000235. GMP_reductase. 1 hit.
TIGRFAMsiTIGR01305. GMP_reduct_1. 1 hit.
PROSITEiView protein in PROSITE
PS00487. IMP_DH_GMP_RED. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A091G9F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRVDVDLKL DFKDVLLRPK RSSLKSRSEV DLTRTFTFRN SKQTYTGIPI
60 70 80 90 100
IVANMDTVGT FEMAMVMAKH SMFTAIHKHY SLEEWKLFAA NHPECLEHVA
110 120 130 140 150
ASSGSGKADF NKLTSILEAI PPIRYICLDV ANGYSEHFVE FVKSVRAKFP
160 170 180 190 200
HHTIMAGNVV TGEMVEELIL SGADIIKVGI GPGSVCTTRI KTGVGYPQLS
210 220 230 240 250
AVIECADSAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM LGGMFAGHDQ
260 270 280 290 300
CAGEIMEKNG KKVKLFYGMS SDTAMKKHAG GVAEYRASEG RTVEVPYRGD
310 320 330 340
VELTILDILG GLRSTCTYVG AAKLKELSRR TTFIRVTQQH SQVFS
Length:345
Mass (Da):37,490
Last modified:November 26, 2014 - v1
Checksum:iFD3910F10BFC50E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KL447914 Genomic DNA. Translation: KFO78588.1.
RefSeqiXP_009562448.1. XM_009564153.1.

Genome annotation databases

GeneIDi104062123.

Similar proteinsi

Entry informationi

Entry nameiA0A091G9F3_9AVES
AccessioniPrimary (citable) accession number: A0A091G9F3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: March 28, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported