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Protein

L-lactate dehydrogenase

Gene

H920_02022

Organism
Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (H920_02022), L-lactate dehydrogenase (H920_05765), L-lactate dehydrogenase (H920_19870)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei153SubstrateUniRule annotation1
Binding sitei185SubstrateUniRule annotation1
Binding sitei216SubstrateUniRule annotation1
Active sitei240Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
ORF Names:H920_02022Imported
OrganismiFukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)Imported
Taxonomic identifieri885580 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaBathyergidaeFukomys
Proteomesi
  • UP000028990 Componenti: Unassembled WGS sequence

Subcellular locationi

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 207Ldh_1_NInterPro annotationAdd BLAST139
Domaini211 – 376Ldh_1_CInterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A091E1I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRRVESPT ATFRDRGKMA DQRTQNKEKS HYYRSFQGTL KEIQCKMATL
60 70 80 90 100
KDKLIAPVAE EEAGLPNNKI TVVGVGQVGM ACAISILGKS LADELALVDV
110 120 130 140 150
LEDKLKGEMM DLQHGSLFLQ TSKIVADKDY SVTANSKIVV VTAGVRQQEG
160 170 180 190 200
ESRLNLVQRN VNVFKFIIPQ IVKYSPDCII IVVSNPVDIL TYVTWKLSGL
210 220 230 240 250
PKHRVIGSGC NLDSARFRYL MAEKLGIHPS SCHGWILGEH GDSSVAVWSG
260 270 280 290 300
VNVAGVSLQE LNPEMGTDSD SENWKEVHKM VVESAYEVIK LKGYTNWAIG
310 320 330 340 350
LSVADLIESI LKNLSRIHPV STMVKGMYGI ENEVFLSLPC ILNARGLTSV
360 370 380
INQKLKDEEV AQLKKSADTL WDIQKDLKDL
Length:380
Mass (Da):42,043
Last modified:November 26, 2014 - v1
Checksum:i01397D6F54029ADA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN121399 Genomic DNA. Translation: KFO36568.1.

Similar proteinsi

Entry informationi

Entry nameiA0A091E1I6_FUKDA
AccessioniPrimary (citable) accession number: A0A091E1I6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: November 22, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported