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Protein
Submitted name:

Rho guanine nucleotide exchange factor (GEF) 5

Gene

ARHGEF5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor (GEF) 5Imported
Gene namesi
Name:ARHGEF5Imported
ORF Names:tcag7.492Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000050327.14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiA0A090N7S2.

Expressioni

Gene expression databases

BgeeiENSG00000050327.
ExpressionAtlasiA0A090N7S2. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A090N7S2.
SMRiA0A090N7S2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 280DHInterPro annotationAdd BLAST185
Domaini312 – 424PHInterPro annotationAdd BLAST113
Domaini432 – 493SH3InterPro annotationAdd BLAST62

Keywords - Domaini

SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3523. Eukaryota.
COG5422. LUCA.

Family and domain databases

CDDicd00160. RhoGEF. 1 hit.
Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR035899. DBL_dom_sf.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH-like_dom_sf.
IPR001849. PH_domain.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A090N7S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGFSRRCSK LINSSQLLYQ EYSDVVLNKE IQSQQRLESL SETPGPSSPR
60 70 80 90 100
QPRKALVSSE SYLQRLSMAS SGSLWQEIPV VRNSTVLLSM THEDQKLQEV
110 120 130 140 150
KFELIVSEAS YLRSLNIAVD HFQLSTSLRA TLSNQEHQWL FSRLQDVRDV
160 170 180 190 200
SATFLSDLEE NFENNIFSFQ VCDVVLNHAP DFRRVYLPYV TNQTYQERTF
210 220 230 240 250
QSLMNSNSNF REVLEKLESD PVCQRLSLKS FLILPFQRIT RLKLLLQNIL
260 270 280 290 300
KRTQPGSSEE AEATKAHHAL EQLIRDCNNN VQSMRRTEEL IYLSQKIEFE
310 320 330 340 350
CKIFPLISQS RWLVKSGELT ALEFSASPGL RRKLNTRPVH LHLFNDCLLL
360 370 380 390 400
SRPREGSRFL VFDHAPFSSI RGEKCEMKLH GPHKNLFRLF LRQNTQGAQA
410 420 430 440 450
EFLFRTETQS EKLRWISALA MPREELDLLE CYNSPQVQCL RAYKPRENDE
460 470 480 490 500
LALEKADVVM VTQQSSDGWL EGVRLSDGER GWFPVQQVEF ISNPEVRAQN
510
LKEAHRVKTA KLQLVEQQA
Length:519
Mass (Da):60,056
Last modified:November 26, 2014 - v1
Checksum:i2EE2C16B3F42C053
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACC02000041 Genomic DNA. Translation: EAL24413.1.
UniGeneiHs.334.
Hs.534621.

Similar proteinsi

Entry informationi

Entry nameiA0A090N7S2_HUMAN
AccessioniPrimary (citable) accession number: A0A090N7S2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: November 22, 2017
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported