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Protein
Submitted name:

E3 ubiquitin-protein ligase Midline-1

Gene

MID1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase Midline-1Imported
Gene namesi
Name:MID1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000101871.14
HGNCiHGNC:7095 MID1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101871

PTM / Processingi

Proteomic databases

EPDiA0A087X255
PeptideAtlasiA0A087X255

Expressioni

Gene expression databases

BgeeiENSG00000101871
ExpressionAtlasiA0A087X255 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A087X255
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 60RING-typeInterPro annotationAdd BLAST51
Domaini170 – 212B box-typeInterPro annotationAdd BLAST43
Domaini371 – 430COSInterPro annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili209 – 247Sequence analysisAdd BLAST39

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118878

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di2.60.40.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR003649 Bbox_C
IPR017903 COS_domain
IPR013783 Ig-like_fold
IPR027727 MID1
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR44073:SF3 PTHR44073:SF3, 2 hits
PfamiView protein in Pfam
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS51262 COS, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A087X255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLESELTC PICLELFEDP LLLPCAHSLC FNCAHRILVS HCATNESVES
60 70 80 90 100
ITAFQCPTCR HVITLSQRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSET
110 120 130 140 150
RRERAFDANT MTSAEKVLCQ FCDQDPAQDA VKTCVTCEVS YCDECLKATH
160 170 180 190 200
PNKKPFTGHR LIEPIPDSHI RGLMCLEHED EKVNMYCVTD DQLICALCKL
210 220 230 240 250
VGRHRDHQVA ALSERYDKLK QNLESNLTNL IKRNTELETL LAKLIQTCQH
260 270 280 290 300
VETVKDQKVI GREKQQYYPR NRRKWVSNSL QARLMGRRCI SRRERKLTLD
310 320 330 340 350
VEKVNASRQE AKLTEECDLL IEIIQQRRQI IGTKIKEGKV MRLRKLAQQI
360 370 380 390 400
ANCKQCIERS ASLISQAEHS LKENDHARFL QTAKNITERV SMATASSQVL
410 420 430 440 450
IPEINLNDTF DTFALDFSRE KKLLECLDYL TAPNPPTIRE ELCTASYDTI
460 470 480 490 500
TVHWTSDDEF SVVSYELQYT IFTGQANVVS EYLMAYLFLS LVAFFRLIAF
510 520 530 540
LNLNFKGRQG RKEHTIFIDL SFLNKKVIAL TCTTLVKTAG
Length:540
Mass (Da):61,708
Last modified:October 29, 2014 - v1
Checksum:iEA6B68F66A99CEAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002349 Genomic DNA No translation available.
AC008008 Genomic DNA No translation available.
AC117406 Genomic DNA No translation available.
KC877957 Genomic DNA No translation available.
U96409 Genomic DNA No translation available.
RefSeqiNP_001180207.1, NM_001193278.1
XP_016885030.1, XM_017029541.1
UniGeneiHs.27695
Hs.460482
Hs.689953
Hs.738954

Genome annotation databases

EnsembliENST00000616003; ENSP00000484712; ENSG00000101871
GeneIDi4281
UCSCiuc004ctm.2 human

Similar proteinsi

Entry informationi

Entry nameiA0A087X255_HUMAN
AccessioniPrimary (citable) accession number: A0A087X255
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: May 23, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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