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Protein

Protein kinase C

Gene

PRKCQ

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase CUniRule annotationSAAS annotation (EC:2.7.11.13UniRule annotationSAAS annotation)
Gene namesi
Name:PRKCQImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000065675.14.
HGNCiHGNC:9410. PRKCQ.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000065675.

PTM / Processingi

Proteomic databases

PaxDbiA0A087X0I9.
PeptideAtlasiA0A087X0I9.

Expressioni

Gene expression databases

BgeeiENSG00000065675.
ExpressionAtlasiA0A087X0I9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A087X0I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 173Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini195 – 245Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini344 – 598Protein kinaseInterPro annotationAdd BLAST255
Domaini599 – 670AGC-kinase C-terminalInterPro annotationAdd BLAST72

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126964.

Family and domain databases

CDDicd00029. C1. 2 hits.
cd05619. STKc_nPKC_theta. 1 hit.
InterProiView protein in InterPro
IPR000961. AGC-kinase_C.
IPR035892. C2_domain_sf.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR034668. nPKC_theta.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR014376. Prot_kin_PKC_delta.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
PIRSFiPIRSF000551. PKC_delta. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiView protein in SMART
SM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 2 hits.

Sequencei

Sequence statusi: Complete.

A0A087X0I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNENGQMYI QKKPTMYPPW DSTFDAHINK GRVMQIIVKG KNVDLISETT
60 70 80 90 100
VELYSLAERC RKNNGKTEIW LELKPQGRML MNARYFLEMS DTKDMNEFET
110 120 130 140 150
EGFFALHQRR GAIKQAKVHH VKCHEFTATF FPQPTFCSVC HEFVWGLNKQ
160 170 180 190 200
GYQCRQCNAA IHKKCIDKVI AKCTGSAINS RETMFHKERF KIDMPHRFKV
210 220 230 240 250
YNYKSPTFCE HCGTLLWGLA RQGLKCDACG MNVHHRCQTK VANLCGINQK
260 270 280 290 300
LMAEALAMIE STQQARCLRD TEQIFREGPV EIGLPCSIKN EARPPCLPTP
310 320 330 340 350
GKREPQGISW ESPLDEVDKM CHLPEPELNK ERPSLQIKLK IEDFILHKML
360 370 380 390 400
GKGSFGKVFL AEFKKTNQFF AIKALKKDVV LMDDDVECTM VEKRVLSLAW
410 420 430 440 450
EHPFLTHMFC TFQTKENLFF VMEYLNGGDL MYHIQSCHKF DLSRATFYAA
460 470 480 490 500
EIILGLQFLH SKGIVYRDLK LDNILLDKDG HIKIADFGMC KENMLGDAKT
510 520 530 540 550
NTFCGTPDYI APEILLGQKY NHSVDWWSFG VLLYEMLIGQ SPFHGQDEEE
560 570 580 590 600
LFHSIRMDNP FYPRWLEKEA KDLLVKLFVR EPEKRLGVRG DIRQHPLFRE
610 620 630 640 650
INWEELERKE IDPPFRPKVK SPFDCSNFDK EFLNEKPRLS FADRALINSM
660 670
DQNMFRNFSF MNPGMERLIS
Length:670
Mass (Da):77,969
Last modified:October 29, 2014 - v1
Checksum:i1817DF6F803F47CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137145 Genomic DNA. No translation available.
AL158043 Genomic DNA. No translation available.
KF455200 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000610727; ENSP00000483428; ENSG00000065675.
UCSCiuc057rni.1. human.

Similar proteinsi

Entry informationi

Entry nameiA0A087X0I9_HUMAN
AccessioniPrimary (citable) accession number: A0A087X0I9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: October 25, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported