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Protein
Submitted name:

Proprotein convertase subtilisin/kexin type 6

Gene

PCSK6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Proprotein convertase subtilisin/kexin type 6Imported
Gene namesi
Name:PCSK6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140479.16.
HGNCiHGNC:8569. PCSK6.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140479.

PTM / Processingi

Proteomic databases

PaxDbiA0A087WZR0.
PeptideAtlasiA0A087WZR0.

Expressioni

Gene expression databases

BgeeiENSG00000140479.
ExpressionAtlasiA0A087WZR0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A087WZR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini685 – 734EGF-likeInterPro annotationAdd BLAST50
Domaini735 – 768EGF-likeInterPro annotationAdd BLAST34
Domaini786 – 816EGF-likeInterPro annotationAdd BLAST31
Domaini834 – 865EGF-likeInterPro annotationAdd BLAST32

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.

Family and domain databases

CDDicd04059. Peptidases_S8_Protein_converta. 1 hit.
Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiView protein in InterPro
IPR000742. EGF-like_dom.
IPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR034182. Kexin/furin.
IPR009020. Peptidase/Inhibitor_I9.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
PfamiView protein in Pfam
PF14843. GF_recep_IV. 1 hit.
PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
PRINTSiPR00723. SUBTILISIN.
SMARTiView protein in SMART
SM00181. EGF. 4 hits.
SM00261. FU. 4 hits.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A087WZR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRAPPAPG PRPPPRAAAA TDTAAGAGGA GGAGGAGGPG FRPLAPRPWR
60 70 80 90 100
WLLLLALPAA CSAPPPRPVY TNHWAVQVLG GPAEADRVAA AHGYLNLGQI
110 120 130 140 150
GNLEDYYHFY HSKTFKRSTL SSRGPHTFLR MDPQVKWLQQ QEVKRRVKRQ
160 170 180 190 200
VRSDPQALYF NDPIWSNMWY LHCGDKNSRC RSEMNVQAAW KRGYTGKNVV
210 220 230 240 250
VTILDDGIER NHPDLAPNYD SYASYDVNGN DYDPSPRYDA SNENKHGTRC
260 270 280 290 300
AGEVAASANN SYCIVGIAYN AKIGGIRMLD GDVTDVVEAK SLGIRPNYID
310 320 330 340 350
IYSASWGPDD DGKTVDGPGR LAKQAFEYGI KKGRQGLGSI FVWASGNGGR
360 370 380 390 400
EGDYCSCDGY TNSIYTISVS SATENGYKPW YLEECASTLA TTYSSGAFYE
410 420 430 440 450
RKIVTTDLRQ RCTDGHTGTS VSAPMVAGII ALALEANSQL TWRDVQHLLV
460 470 480 490 500
KTSRPAHLKA SDWKVNGAGH KVSHFYGFGL VDAEALVVEA KKWTAVPSQH
510 520 530 540 550
MCVAASDKRP RSIPLVQVLR TTALTSACAE HSDQRVVYLE HVVVRTSISH
560 570 580 590 600
PRRGDLQIYL VSPSGTKSQL LAKRLLDLSN EGFTNWEFMT VHCWGEKAEG
610 620 630 640 650
QWTLEIQDLP SQVRNPEKQG KLKEWSLILY GTAEHPYHTF SAHQSRSRML
660 670 680 690 700
ELSAPELEPP KAALSPSQVE VPEDEEDYTG VCHPECGDKG CDGPNADQCL
710 720 730 740 750
NCVHFSLGSV KTSRKCVSVC PLGYFGDTAA RRCRRCHKGC ETCSSRAATQ
760 770 780 790 800
CLSCRRGFYH HQEMNTCVTL CPAGFYADES QKNCLKCHPS CKKCVDEPEK
810 820 830 840 850
CTVCKEGFSL ARGSCIPDCE PGTYFDSELI RCGECHHTCG TCVGPGREEC
860 870 880 890 900
IHCAKNFHFH DWKCVPACGE GFYPEEMPGL PHKVCRRYGP PGGERQAAVS
910 920 930 940 950
SKGVPGGQSL AASSPGAGEG MLHHPTVDRS PFTELLRGLR PFVHWMHICW
960
VPAVGRHRAA AG
Length:962
Mass (Da):105,329
Last modified:October 29, 2014 - v1
Checksum:iED06CF91BCAE40E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023024 Genomic DNA. No translation available.
AC087528 Genomic DNA. No translation available.
AC090164 Genomic DNA. No translation available.
AMYH02031172 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000619160; ENSP00000482831; ENSG00000140479.
UCSCiuc032csl.2. human.

Similar proteinsi

Entry informationi

Entry nameiA0A087WZR0_HUMAN
AccessioniPrimary (citable) accession number: A0A087WZR0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: September 27, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported