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Protein
Submitted name:

5-hydroxytryptamine receptor 2A

Gene

HTR2A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
5-hydroxytryptamine receptor 2AImported
Gene namesi
Name:HTR2AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102468.10.
HGNCiHGNC:5293. HTR2A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 68HelicalSequence analysisAdd BLAST24
Transmembranei80 – 106HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000102468.

Expressioni

Gene expression databases

BgeeiENSG00000102468.
ExpressionAtlasiA0A087WZJ9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A087WZJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 110G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST51

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00890000139331.

Family and domain databases

InterProiView protein in InterPro
IPR000455. 5HT2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PANTHERiPTHR24247:SF30. PTHR24247:SF30. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00516. 5HT2ARECEPTR.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

A0A087WZJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FNSGEANTSD AFNWTVDSEN RTNLSCEGCL SPSCLSLLHL QEKNWSALLT
60 70 80 90 100
AVVIILTIAG NILVIMAVSL EKKLQNATNY FLMSLAIADM LLGFLVMPVS
110
MLTILYGEWH
Length:110
Mass (Da):12,096
Last modified:October 29, 2014 - v1
Checksum:i7428BC46F5DB383C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136958 Genomic DNA. No translation available.
AL160397 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000612998; ENSP00000482708; ENSG00000102468.
UCSCiuc058wxl.1. human.

Entry informationi

Entry nameiA0A087WZJ9_HUMAN
AccessioniPrimary (citable) accession number: A0A087WZJ9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: January 31, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported