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Protein

Proteasome endopeptidase complex

Gene

PSMA8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteasePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome endopeptidase complexPROSITE-ProRule annotation (EC:3.4.25.1PROSITE-ProRule annotation)
Gene namesi
Name:PSMA8Imported
ORF Names:hCG_38481Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000154611.14.
HGNCiHGNC:22985. PSMA8.

Subcellular locationi

Keywords - Cellular componenti

CytoplasmPROSITE-ProRule annotation, ProteasomePROSITE-ProRule annotationImported

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000154611.

Expressioni

Gene expression databases

BgeeiENSG00000154611.
ExpressionAtlasiA0A087WYS6. baseline and differential.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili198 – 224Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0183. Eukaryota.
ENOG410XP21. LUCA.
GeneTreeiENSGT00550000074753.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR001353. Proteasome_sua/b.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A087WYS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVCTFEKVG IRGTNIVVLG VEKKSVAKLQ DERTVRKICA LDDHVCMAFA
60 70 80 90 100
GLTADARVVI NRARVECQSH KLTVEDPVTV EYITRFIATL KQKYTQSNGR
110 120 130 140 150
RPFGISALIV GFDDDGISRL YQTDPSGTYH AWKANAIGRS AKTVREFLEK
160 170 180 190 200
NYTEDAIASD SEAIKLAIKA LLEVVQSGGK NIELAIIRRN QPLKMFSAKE
210 220
VELYVTEIEK EKEEAEKKKS KKSV
Length:224
Mass (Da):25,041
Last modified:October 29, 2014 - v1
Checksum:i9C52C06AC7AB560F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016839 Genomic DNA. No translation available.
AC091021 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01215.1.
RefSeqiNP_001295117.1. NM_001308188.1.
UniGeneiHs.464813.

Genome annotation databases

EnsembliENST00000612461; ENSP00000482057; ENSG00000154611.
GeneIDi143471.
UCSCiuc060odf.1. human.

Similar proteinsi

Entry informationi

Entry nameiA0A087WYS6_HUMAN
AccessioniPrimary (citable) accession number: A0A087WYS6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: September 27, 2017
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported