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Protein
Submitted name:

Neural cell adhesion molecule 1

Gene

NCAM1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Neural cell adhesion molecule 1Imported
Gene namesi
Name:NCAM1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149294.16
HGNCiHGNC:7656 NCAM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei749 – 772HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149294

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500183198420 – 884Sequence analysisAdd BLAST865

Proteomic databases

PeptideAtlasiA0A087WWD4
PRIDEiA0A087WWD4

Expressioni

Gene expression databases

BgeeiENSG00000149294
ExpressionAtlasiA0A087WWD4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A087WWD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 111Ig-likeInterPro annotationAdd BLAST92
Domaini116 – 189Ig-likeInterPro annotationAdd BLAST74
Domaini212 – 301Ig-likeInterPro annotationAdd BLAST90
Domaini308 – 439Ig-likeInterPro annotationAdd BLAST132
Domaini442 – 527Ig-likeInterPro annotationAdd BLAST86
Domaini535 – 634Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini637 – 732Fibronectin type-IIIInterPro annotationAdd BLAST96

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQJI Eukaryota
ENOG410XTGB LUCA
GeneTreeiENSGT00910000144011

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.106 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR033019 Ncam1
IPR009138 Neural_cell_adh
PANTHERiPTHR44059:SF2 PTHR44059:SF2, 2 hits
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits
PRINTSiPR01838 NCAMFAMILY
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 5 hits

Sequencei

Sequence statusi: Complete.

A0A087WWD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK
60 70 80 90 100
DISWFSPNGE KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTG
110 120 130 140 150
EDGSESEATV NVKIFQKLMF KNAPTPQEFR EGEDAVIVCD VVSSLPPTII
160 170 180 190 200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN
210 220 230 240 250
FKDIQVIVNV PPTIQARQNI VNATANLGQS VTLVCDAEGF PEPTMSWTKD
260 270 280 290 300
GEQIEQEEDD EKYIFSDDSS QLTIKKVDKN DEAEYICIAE NKAGEQDATI
310 320 330 340 350
HLKVFAKPKI TYVENQTAME LEEQVTLTCE ASGDPIPSIT WRTSTRNISS
360 370 380 390 400
EEKASWTRPE KQEVHAPWNW QVGRQKGQAG SAGFPGSHET LDGHMVVRSH
410 420 430 440 450
ARVSSLTLKS IQYTDAGEYI CTASNTIGQD SQSMYLEVQY APKLQGPVAV
460 470 480 490 500
YTWEGNQVNI TCEVFAYPSA TISWFRDGQL LPSSNYSNIK IYNTPSASYL
510 520 530 540 550
EVTPDSENDF GNYNCTAVNR IGQESLEFIL VQADTPSSPS IDQVEPYSST
560 570 580 590 600
AQVQFDEPEA TGGVPILKYK AEWRAVGEEV WHSKWYDAKE ASMEGIVTIV
610 620 630 640 650
GLKPETTYAV RLAALNGKGL GEISAASEFK TQPVQGEPSA PKLEGQMGED
660 670 680 690 700
GNSIKVNLIK QDDGGSPIRH YLVRYRALSS EWKPEIRLPS GSDHVMLKSL
710 720 730 740 750
DWNAEYEVYV VAENQQGKSK AAHFVFRTSA QPTAIPANGS PTSGLSTGAI
760 770 780 790 800
VGILIVIFVL LLVVVDITCY FLNKCGLFMC IAVNLCGKAG PGAKGKDMEE
810 820 830 840 850
GKAAFSKDES KEPIVEVRTE EERTPNHDGG KHTEPNETTP LTEPEKGPVE
860 870 880
AKPECQETET KPAPAEVKTV PNDATQTKEN ESKA
Length:884
Mass (Da):97,345
Last modified:October 29, 2014 - v1
Checksum:i2CED586CAA41E9F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000802 Genomic DNA No translation available.
AP000999 Genomic DNA No translation available.
AP002853 Genomic DNA No translation available.
FP884230 Genomic DNA No translation available.
KF455513 Genomic DNA No translation available.
KF455515 Genomic DNA No translation available.
KF455518 Genomic DNA No translation available.
KF511120 Genomic DNA No translation available.
RefSeqiNP_001229536.1, NM_001242607.1
UniGeneiHs.503878
Hs.711235
Hs.733031

Genome annotation databases

EnsembliENST00000619839; ENSP00000480132; ENSG00000149294
GeneIDi4684
UCSCiuc058hjr.1 human

Similar proteinsi

Entry informationi

Entry nameiA0A087WWD4_HUMAN
AccessioniPrimary (citable) accession number: A0A087WWD4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: March 28, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported