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UniProtKB - A0A087WWD4 (A0A087WWD4_HUMAN)

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Protein
Submitted name:

Neural cell adhesion molecule 1

Gene

NCAM1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neural cell adhesion molecule 1Imported
Gene namesi
Name:NCAM1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:7656. NCAM1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei749 – 772HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500183198420 – 884Sequence analysisAdd BLAST865

Proteomic databases

PaxDbiA0A087WWD4.
PeptideAtlasiA0A087WWD4.
PRIDEiA0A087WWD4.

Expressioni

Gene expression databases

ExpressionAtlasiA0A087WWD4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000318472.

Structurei

3D structure databases

ProteinModelPortaliA0A087WWD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 111Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST92
Domaini116 – 189Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST74
Domaini212 – 301Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST90
Domaini308 – 439Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST132
Domaini442 – 527Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST86
Domaini535 – 634Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini637 – 732Fibronectin type-IIIInterPro annotationAdd BLAST96

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQJI. Eukaryota.
ENOG410XTGB. LUCA.
GeneTreeiENSGT00860000133697.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 7 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR009138. Neural_cell_adh.
PfamiView protein in Pfam
PF00041. fn3. 2 hits.
PF07679. I-set. 3 hits.
PRINTSiPR01838. NCAMFAMILY.
SMARTiView protein in SMART
SM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiView protein in PROSITE
PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.

Sequencei

Sequence statusi: Complete.

A0A087WWD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK 
        60         70         80         90        100
DISWFSPNGE KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTG 
       110        120        130        140        150
EDGSESEATV NVKIFQKLMF KNAPTPQEFR EGEDAVIVCD VVSSLPPTII 
       160        170        180        190        200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN 
       210        220        230        240        250
FKDIQVIVNV PPTIQARQNI VNATANLGQS VTLVCDAEGF PEPTMSWTKD 
       260        270        280        290        300
GEQIEQEEDD EKYIFSDDSS QLTIKKVDKN DEAEYICIAE NKAGEQDATI 
       310        320        330        340        350
HLKVFAKPKI TYVENQTAME LEEQVTLTCE ASGDPIPSIT WRTSTRNISS 
       360        370        380        390        400
EEKASWTRPE KQEVHAPWNW QVGRQKGQAG SAGFPGSHET LDGHMVVRSH 
       410        420        430        440        450
ARVSSLTLKS IQYTDAGEYI CTASNTIGQD SQSMYLEVQY APKLQGPVAV 
       460        470        480        490        500
YTWEGNQVNI TCEVFAYPSA TISWFRDGQL LPSSNYSNIK IYNTPSASYL 
       510        520        530        540        550
EVTPDSENDF GNYNCTAVNR IGQESLEFIL VQADTPSSPS IDQVEPYSST 
       560        570        580        590        600
AQVQFDEPEA TGGVPILKYK AEWRAVGEEV WHSKWYDAKE ASMEGIVTIV 
       610        620        630        640        650
GLKPETTYAV RLAALNGKGL GEISAASEFK TQPVQGEPSA PKLEGQMGED 
       660        670        680        690        700
GNSIKVNLIK QDDGGSPIRH YLVRYRALSS EWKPEIRLPS GSDHVMLKSL 
       710        720        730        740        750
DWNAEYEVYV VAENQQGKSK AAHFVFRTSA QPTAIPANGS PTSGLSTGAI 
       760        770        780        790        800
VGILIVIFVL LLVVVDITCY FLNKCGLFMC IAVNLCGKAG PGAKGKDMEE 
       810        820        830        840        850
GKAAFSKDES KEPIVEVRTE EERTPNHDGG KHTEPNETTP LTEPEKGPVE 
       860        870        880 
AKPECQETET KPAPAEVKTV PNDATQTKEN ESKA
Length:884
Mass (Da):97,345
Last modified:October 29, 2014 - v1
Checksum:i2CED586CAA41E9F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000802 Genomic DNA. No translation available.
AP000999 Genomic DNA. No translation available.
AP002853 Genomic DNA. No translation available.
FP884230 Genomic DNA. No translation available.
KF455513 Genomic DNA. No translation available.
KF455515 Genomic DNA. No translation available.
KF455518 Genomic DNA. No translation available.
KF511120 Genomic DNA. No translation available.
RefSeqiNP_001229536.1. NM_001242607.1.
UniGeneiHs.503878.
Hs.711235.
Hs.733031.

Genome annotation databases

EnsembliENST00000619839; ENSP00000480132; ENSG00000149294.
GeneIDi4684.
UCSCiuc058hjr.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000802 Genomic DNA. No translation available.
AP000999 Genomic DNA. No translation available.
AP002853 Genomic DNA. No translation available.
FP884230 Genomic DNA. No translation available.
KF455513 Genomic DNA. No translation available.
KF455515 Genomic DNA. No translation available.
KF455518 Genomic DNA. No translation available.
KF511120 Genomic DNA. No translation available.
RefSeqiNP_001229536.1. NM_001242607.1.
UniGeneiHs.503878.
Hs.711235.
Hs.733031.

3D structure databases

ProteinModelPortaliA0A087WWD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318472.

Proteomic databases

PaxDbiA0A087WWD4.
PeptideAtlasiA0A087WWD4.
PRIDEiA0A087WWD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000619839; ENSP00000480132; ENSG00000149294.
GeneIDi4684.
UCSCiuc058hjr.1. human.

Organism-specific databases

CTDi4684.
HGNCiHGNC:7656. NCAM1.
OpenTargetsiENSG00000149294.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJI. Eukaryota.
ENOG410XTGB. LUCA.
GeneTreeiENSGT00860000133697.

Miscellaneous databases

GenomeRNAii4684.

Gene expression databases

ExpressionAtlasiA0A087WWD4. baseline and differential.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 7 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR009138. Neural_cell_adh.
PfamiView protein in Pfam
PF00041. fn3. 2 hits.
PF07679. I-set. 3 hits.
PRINTSiPR01838. NCAMFAMILY.
SMARTiView protein in SMART
SM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiView protein in PROSITE
PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiA0A087WWD4_HUMAN
AccessioniPrimary (citable) accession number: A0A087WWD4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: June 7, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.