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Protein
Submitted name:

ATP-binding cassette sub-family B member 7, mitochondrial

Gene

ABCB7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi466 – 473ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette sub-family B member 7, mitochondrialImported
Gene namesi
Name:ABCB7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000131269.15.
HGNCiHGNC:48. ABCB7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei221 – 248HelicalSequence analysisAdd BLAST28
Transmembranei254 – 275HelicalSequence analysisAdd BLAST22
Transmembranei344 – 366HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131269.

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A087WW65.
PRIDEiA0A087WW65.

Expressioni

Gene expression databases

BgeeiENSG00000131269.
ExpressionAtlasiA0A087WW65. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A087WW65.
SMRiA0A087WW65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 397ABC transmembrane type-1InterPro annotationAdd BLAST286
Domaini433 – 667ABC transporterInterPro annotationAdd BLAST235

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili680 – 700Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00440000033373.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A087WW65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLAMHSWR WAAAAAAFEK RRHSAILIRP LVSVSGSGPQ WRPHQLGALG
60 70 80 90 100
TARAYQQIPE SLKSITWQRL GKGNSGQFLD AAKALQVWPL IEKRTCWHGH
110 120 130 140 150
AGGGLHTDPK EGAMNIVVPF MFKYAVDSLN QMSGNMLNLS DAPNTVATMA
160 170 180 190 200
TAVLIGYGVS RAGAAFFNEV RNAVFGKVAQ NSIRRIAKNV FLHLHNLDLG
210 220 230 240 250
FHLSRQTGAL SKAIDRGTRG ISFVLSALVF NLLPIMFEVM LVSGVLYYKC
260 270 280 290 300
GAQFALVTLG TLGTYTAFTV AVTRWRTRFR IEMNKADNDA GNAAIDSLLN
310 320 330 340 350
YETVKYFNNE RYEAQRYDGF LKTYETASLK STSTLAMLNF GQSAIFSVGL
360 370 380 390 400
TAIMVLASQG IVAGTLTVGD LVMVNGLLFQ LSLPLNFLGT VYRETRQALI
410 420 430 440 450
DMNTLFTLLK VDTQIKDKVM ASPLQITPQT ATVAFDNVHF EYIEGQKVLS
460 470 480 490 500
GISFEVPAGK KVAIVGGSGS GKSTIVRLLF RFYEPQKGSI YLAGQNIQDV
510 520 530 540 550
SLESLRRAVG VVPQDAVLFH NTIYYNLLYG NISASPEEVY AVAKLAGLHD
560 570 580 590 600
AILRMPHGYD TQVGERGLKL SGGEKQRVAI ARAILKDPPV ILYDEATSSL
610 620 630 640 650
DSITEETILG AMKDVVKHRT SIFIAHRLST VVDADEIIVL DQGKVAERGT
660 670 680 690 700
HHGLLANPHS IYSEMWHTQS SRVQNHDNPK WEAKKENISK EEERKKLQEE
710
IVNSVKGCGN CSC
Length:713
Mass (Da):78,288
Last modified:October 29, 2014 - v1
Checksum:iD7D9854F432DDB96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359545 Genomic DNA. No translation available.
AL360179 Genomic DNA. No translation available.
AL590232 Genomic DNA. No translation available.
RefSeqiNP_001258628.1. NM_001271699.1.
UniGeneiHs.370480.

Genome annotation databases

EnsembliENST00000620875; ENSP00000479985; ENSG00000131269.
GeneIDi22.
UCSCiuc010nls.4. human.

Similar proteinsi

Entry informationi

Entry nameiA0A087WW65_HUMAN
AccessioniPrimary (citable) accession number: A0A087WW65
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: December 20, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported