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Protein
Submitted name:

Zinc finger protein 446

Gene

ZNF446

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Zinc finger protein 446Imported
Gene namesi
Name:ZNF446Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000083838.15
HGNCiHGNC:21036 ZNF446

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000083838

Expressioni

Gene expression databases

BgeeiENSG00000083838
ExpressionAtlasiA0A087WUM8 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PGBD1Q96JS33EBI-11955977,EBI-10290053

Protein-protein interaction databases

IntActiA0A087WUM8, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliA0A087WUM8
SMRiA0A087WUM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 107SCAN boxInterPro annotationAdd BLAST82
Domaini332 – 359C2H2-typeInterPro annotationAdd BLAST28
Domaini395 – 422C2H2-typeInterPro annotationAdd BLAST28

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR027764 Zfp18/Zfp446
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR45403 PTHR45403, 2 hits
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequencei

Sequence statusi: Complete.

A0A087WUM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPLGPPCL PVMDPETTLE EPETARLRFR GFCYQEVAGP REALARLREL
60 70 80 90 100
CCQWLQPEAH SKEQMLEMLV LEQFLGTLPP EIQAWVRGQR PGSPEEAAAL
110 120 130 140 150
VEGLQHDPGQ LLGWITAHVL KQEVLPAAQK TEEPLGSPHP SGTVESPGEG
160 170 180 190 200
PQDTRIEGSV QLSCSVKEEP NVDGQEVAPS SPPLAAQSPE GNHGHQEPAS
210 220 230 240 250
TSFHPPRIQE EWGLLDRSQK ELYWDAMLEK YGTVVSLGLP PHQPEAQAQS
260 270 280 290 300
ELGMLLTGTG VCRSLRSGNE SEGPPGCPEA QPPQGPGPAA WEGLSGAATP
310 320 330 340 350
APTVRPGTPP VPTQPTPAET RLEPAATPRK PYTCEQCGRG FDWKSVFVIH
360 370 380 390 400
HRTHTSGPGV QSPGLATGES TEKPPQGEVA FPHHPRRSLT GPRSYPCEEC
410 420
GCSFSWKSQL VIHRKSHRPE VP
Length:422
Mass (Da):45,648
Last modified:October 29, 2014 - v1
Checksum:iD1878D81688F415E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012313 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000610298; ENSP00000478778; ENSG00000083838
UCSCiuc061dti.1 human

Similar proteinsi

Entry informationi

Entry nameiA0A087WUM8_HUMAN
AccessioniPrimary (citable) accession number: A0A087WUM8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: April 25, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health