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Protein
Submitted name:

Pyrroline-5-carboxylate reductase 2

Gene

PYCR2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Pyrroline-5-carboxylate reductase 2Imported
Gene namesi
Name:PYCR2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143811.16.
HGNCiHGNC:30262. PYCR2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143811.

PTM / Processingi

Proteomic databases

PaxDbiA0A087WTV6.
PeptideAtlasiA0A087WTV6.
PRIDEiA0A087WTV6.

Expressioni

Gene expression databases

BgeeiENSG00000143811.
ExpressionAtlasiA0A087WTV6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A087WTV6.
SMRiA0A087WTV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 98F420_oxidoredInterPro annotationAdd BLAST96
Domaini107 – 194P5CR_dimerInterPro annotationAdd BLAST88

Phylogenomic databases

eggNOGiKOG3124. Eukaryota.
COG0345. LUCA.
GeneTreeiENSGT00390000007443.

Family and domain databases

HAMAPiMF_01925. P5C_reductase. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR028939. P5C_Rdtase_cat_N.
IPR029036. P5CR_dimer.
IPR000304. Pyrroline-COOH_reductase.
PANTHERiPTHR11645. PTHR11645. 1 hit.
PfamiView protein in Pfam
PF03807. F420_oxidored. 1 hit.
PF14748. P5CR_dimer. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00521. P5CR. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A087WTV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGFIGAGQ LAYALARGFT AAGILSAHKI IASSPEMNLP TVSALRKMGV
60 70 80 90 100
NLTRSNKETV KHSDVLFLAV KPHIIPFILD EIGADVQARH IVVSCAAGVT
110 120 130 140 150
ISSVEKAFMA LDALADGGVK MGLPRRLAIQ LGAQALLGAA KMLLDSEQHP
160 170 180 190 200
CQLKDNVCSP GGATIHALHF LESGGFRSLL INAVEASCIR TRELQSMADQ
210 220 230 240
EKISPAALKK TLLDRVKLES PTVSTLTPSS PGKLLTRSLA LGGKKD
Length:246
Mass (Da):25,868
Last modified:October 29, 2014 - v1
Checksum:iF7B8C99BC92FFA85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117348 Genomic DNA. No translation available.
RefSeqiNP_001258610.1. NM_001271681.1.
UniGeneiHs.654718.

Genome annotation databases

EnsembliENST00000612039; ENSP00000478165; ENSG00000143811.
GeneIDi29920.
UCSCiuc031psk.1. human.

Similar proteinsi

Entry informationi

Entry nameiA0A087WTV6_HUMAN
AccessioniPrimary (citable) accession number: A0A087WTV6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: September 27, 2017
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported