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Protein
Submitted name:

Receptor-type tyrosine-protein phosphatase eta

Gene

PTPRJ

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1240Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor-type tyrosine-protein phosphatase etaImported
Gene namesi
Name:PTPRJImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149177.12
HGNCiHGNC:9673 PTPRJ

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei975 – 996HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149177

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_500183191136 – 1338Sequence analysisAdd BLAST1303

Proteomic databases

EPDiA0A087WTK0
PeptideAtlasiA0A087WTK0

Expressioni

Gene expression databases

BgeeiENSG00000149177
ExpressionAtlasiA0A087WTK0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A087WTK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 209Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini368 – 456Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini457 – 541Fibronectin type-IIIInterPro annotationAdd BLAST85
Domaini542 – 623Fibronectin type-IIIInterPro annotationAdd BLAST82
Domaini625 – 720Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini721 – 817Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini1042 – 1299Tyrosine-protein phosphataseInterPro annotationAdd BLAST258
Domaini1217 – 1290TYR_PHOSPHATASE_2InterPro annotationAdd BLAST74

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0791 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00900000140785

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.105 hits
3.90.190.101 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF49265 SSF49265, 4 hits
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

A0A087WTK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPAAREARL PPRSPGLRWA LPLLLLLLRL GQILCAGGTP SPIPDPSVAT
60 70 80 90 100
VATGENGITQ ISSTAESFHK QNGTGTPQVE TNTSEDGESS GANDSLRTPE
110 120 130 140 150
QGSNGTDGAS QKTPSSTGPS PVFDIKAVSI SPTNVILTWK SNDTAASEYK
160 170 180 190 200
YVVKHKMENE KTITVVHQPW CNITGLRPAT SYVFSITPGI GNETWGDPRV
210 220 230 240 250
IKVITEPIPV SDLRVALTGV RKAALSWSNG NGTASCRVLL ESIGSHEELT
260 270 280 290 300
QDSRLQVNIS GLKPGVQYNI NPYLLQSNKT KGDPLGTEGG LDASNTERSR
310 320 330 340 350
AGSPTAPVHD ESLVGPVDPS SGQQSRDTEV LLVGLEPGTR YNATVYSQAA
360 370 380 390 400
NGTEGQPQAI EFRTNAIQVF DVTAVNISAT SLTLIWKVSD NESSSNYTYK
410 420 430 440 450
IHVAGETDSS NLNVSEPRAV IPGLRSSTFY NITVCPVLGD IEGTPGFLQV
460 470 480 490 500
HTPPVPVSDF RVTVVSTTEI GLAWSSHDAE SFQMHITQEG AGNSRVEITT
510 520 530 540 550
NQSIIIGGLF PGTKYCFEIV PKGPNGTEGA SRTVCNRTVP SAVFDIHVVY
560 570 580 590 600
VTTTEMWLDW KSPDGASEYV YHLVIESKHG SNHTSTYDKA ITLQGLIPGT
610 620 630 640 650
LYNITISPEV DHVWGDPNST AQYTRPSNVS NIDVSTNTTA ATLSWQNFDD
660 670 680 690 700
ASPTYSYCLL IEKAGNSSNA TQVVTDIGIT DATVTELIPG SSYTVEIFAQ
710 720 730 740 750
VGDGIKSLEP GRKSFCTDPA SMASFDCEVV PKEPALVLKW TCPPGANAGF
760 770 780 790 800
ELEVSSGAWN NATHLESCSS ENGTEYRTEV TYLNFSTSYN ISITTVSCGK
810 820 830 840 850
MAAPTRNTCT TGITDPPPPD GSPNITSVSH NSVKVKFSGF EASHGPIKAY
860 870 880 890 900
AVILTTGEAG HPSADVLKYT YEDFKKGASD TYVTYLIRTE EKGRSQSLSE
910 920 930 940 950
VLKYEIDVGN ESTTLGYYNG KLEPLGSYRA CVAGFTNITF HPQNKGLIDG
960 970 980 990 1000
AESYVSFSRY SDAVSLPQDP GVICGAVFGC IFGALVIVTV GGFIFWRKKR
1010 1020 1030 1040 1050
KDAKNNEVSF SQIKSLKRSK LIRVENFEAY FKKQQADSNC GFAEEYEDLK
1060 1070 1080 1090 1100
LVGISQPKYA AELAENRGKN RYNNVLPYDI SRVKLSVQTH STDDYINANY
1110 1120 1130 1140 1150
MPGYHSKKDF IATQGPLPNT LKDFWRMVWE KNVYAIIMLT KCVEQGRTKC
1160 1170 1180 1190 1200
EEYWPSKQAQ DYGDITVAMT SEIVLPEWTI RDFTVKNIQT SESHPLRQFH
1210 1220 1230 1240 1250
FTSWPDHGVP DTTDLLINFR YLVRDYMKQS PPESPILVHC SAGVGRTGTF
1260 1270 1280 1290 1300
IAIDRLIYQI ENENTVDVYG IVYDLRMHRP LMVQTEDQYV FLNQCVLDIV
1310 1320 1330
RSQKDSKVDL IYQNTTAMTI YENLAPVTTF GKTNGYIA
Length:1,338
Mass (Da):146,073
Last modified:October 29, 2014 - v1
Checksum:i93BB281BC0168A9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026975 Genomic DNA No translation available.
AC103828 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000613246; ENSP00000477933; ENSG00000149177
UCSCiuc058bio.1 human

Similar proteinsi

Entry informationi

Entry nameiA0A087WTK0_HUMAN
AccessioniPrimary (citable) accession number: A0A087WTK0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: March 28, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported