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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109ZincUniRule annotation1
Metal bindingi111ZincUniRule annotation1
Metal bindingi136ZincUniRule annotation1
Metal bindingi138ZincUniRule annotation1
Binding sitei256ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
ORF Names:SY94_4440Imported
OrganismiRhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter)Imported
Taxonomic identifieri358 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000033487 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A083ZJD1
SMRiA0A083ZJD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 322tRNA-synt_1cInterPro annotationAdd BLAST317

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 22"HIGH" regionUniRule annotationAdd BLAST11
Motifi253 – 257"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0A083ZJD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSGVRVRI APSPTGEPHV GTAYIALFNY LFAKKHGGEF ILRIEDTDAT
60 70 80 90 100
RSTLEYEQKV LEALRWTGLT WSEGPDVGGP YGPYRQSERK PMYWPYAEEL
110 120 130 140 150
LEKGHAFRCF CTPERLEQMR EAQRAAGKPP KYDGLCLHLK AEEVTTRVAA
160 170 180 190 200
GEANVVRMKI PTEGSCDFHD GVYGDVSIPW DSVDMQVLIK ADGMPTYHMA
210 220 230 240 250
NVIDDHLMKI THVARGEEWL ASVPKHILLY RYFGWDQPTF MHLSLMRNAD
260 270 280 290 300
KSKLSKRKNP TSISYYSALG YLPEALMNFL GLFFIQIAEG EELLTMEELA
310 320 330 340 350
AKFDPEALSK AGAIFDIQKL DWLNGRWLRE KLTPEDFIAR TLEWAMENSR
360 370 380 390 400
LTEGLKLAQS RISKLGELPN LAGFLVSSDV GLTPASFAGL KSKPEEIHEI
410 420 430 440 450
LTTVAADLEK MPDWNVEAIE AELRDIAERT GKKLRVVTPP LFVAVSGSSR
460 470 480
SLPLFDSMAL LGRSVVRQRL KVAIAVVATM VGSGS
Length:485
Mass (Da):54,228
Last modified:October 29, 2014 - v1
Checksum:i8E74D02F7F383660
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JZLL01000080 Genomic DNA Translation: KJX85796.1
RefSeqiWP_010973882.1, NZ_JZLL01000080.1

Genome annotation databases

EnsemblBacteriaiKJX85796; KJX85796; SY94_4440
PATRICifig|358.65.peg.3458

Similar proteinsi

Entry informationi

Entry nameiA0A083ZJD1_RHIRD
AccessioniPrimary (citable) accession number: A0A083ZJD1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: March 28, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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