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Protein

LexA repressor

Gene

lexA

Organism
Pseudomonas sp. StFLB209
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotation

Catalytic activityi

Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei146For autocatalytic cleavage activityUniRule annotation1
Active sitei183For autocatalytic cleavage activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi50 – 70H-T-H motifUniRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotationSAAS annotation
Biological processDNA damage, DNA repairUniRule annotationSAAS annotation, DNA replicationUniRule annotationSAAS annotation, SOS responseUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
LexA repressorUniRule annotation (EC:3.4.21.88UniRule annotation)
Gene namesi
Name:lexAUniRule annotation
ORF Names:PSCI_5475Imported
OrganismiPseudomonas sp. StFLB209Imported
Taxonomic identifieri1028989 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000031652 Componenti: Chromosome

PTM / Processingi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei111 – 112Cleavage; by autolysisUniRule annotation2

Keywords - PTMi

Autocatalytic cleavageUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 87LexA_DNA_bindInterPro annotationAdd BLAST65
Domaini141 – 207Peptidase_S24InterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the peptidase S24 family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01356.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00015. LexA. 1 hit.
InterProiView protein in InterPro
IPR006200. LexA.
IPR036286. LexA/Signal_pep-like_sf.
IPR006199. LexA_DNA-bd_dom.
IPR006197. Peptidase_S24_LexA.
IPR015927. Peptidase_S24_S26A/B/C.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
PRINTSiPR00726. LEXASERPTASE.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR00498. lexA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A077LQ27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAKPPSLYI IPVTVQKDRA HDMIKLTPRQ AEILDFIKRC LEDNGYPPTR
60 70 80 90 100
AEIAQKLGFK SPNAAEEHLK ALARKGAIEM TPGASRGIRI PGFEARQADD
110 120 130 140 150
SSLPIIGRVA AGAPILAQQH IEESCNINPT FFHPSADYLL RVHGMSMKDV
160 170 180 190 200
GILDGDLLAV HTTREARNGQ IVVARIGDEV TVKRFKREGN KVWLIAENPE
210 220
FAPIEVDLKE QELVIEGLSV GVLRR
Length:225
Mass (Da):24,870
Last modified:October 29, 2014 - v1
Checksum:i6F67AD18F69471C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP014637 Genomic DNA. Translation: BAP46177.1.

Genome annotation databases

EnsemblBacteriaiBAP46177; BAP46177; PSCI_5475.
KEGGipses:PSCI_5475.

Similar proteinsi

Entry informationi

Entry nameiA0A077LQ27_9PSED
AccessioniPrimary (citable) accession number: A0A077LQ27
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: October 25, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported